Browsing Faculty of Health Sciences by Subject "Cardiovascular pharmacology"

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Cardiovascular safety pharmacology studies in dogs enabled for a poorly soluble molecule using spray-dried dispersion: impact on lead selection

Tseng, Yin-Chao; Guth, Brian; Linehan, Brian; Ng, Khing Jow; Smith, Dustin M, (Elsevier, 2016)

The aim of this study was to identify an adequate formulation for a poorly soluble lead molecule (BI-A) that would achieve sufficiently high plasma concentrations after oral administration in dogs to enable a robust ...