Browsing Faculty of Health Sciences by Subject "CDK9/CyclinT"

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Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors

Qhobosheane, Malikotsi A.; Legoabe, Lesetja J.; Petzer, Jacobus P.; Beteck, Richard M.; Josselin, Béatrice (Elsevier, 2020)

Protein kinases are important drug targets, especially in the area of oncology. This paper reports the synthesis and biological evaluation of new 7-azaindole derivatives bearing benzocycloalkanone motifs as potential protein ...
Synthesis and evaluation of C3 substituted chalcone-based derivatives of 7-azaindole as protein kinase inhibitors

Qhobosheane, Malikotsi A.; Legoabe, Lesetja J.; Beteck, Richard M.; Josselin, Béatrice; Bach, Stéphane (Wiley, 2020)

Chalcones are a group of naturally occurring or synthetic compounds which possess a wide range of biological activities. In this paper, a series of twenty‐three 7‐azaindole‐chalcone hybrids (5a–w) were synthesized and ...