Browsing Faculty of Health Sciences by Subject "Antimalarials"

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Antimalarial N-1,N-3-dialkyldioxonaphthoimidazoliums: synthesis, biological activity, and structure-activity relationships

Ahenkorah, Stephen; Haynes, Richard; Coertzen, Dina; Tong, Jie Xin; Fridianto, Kevin (ACS, 2020)

Here we report the nanomolar potencies of N1,N3-dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant Plasmodium falciparum. Activity was dependent on the presence of the fused quinone-imidazolium ...
Development of pyridyl thiosemicarbazones as highly potent agents for the treatment of malaria after oral administration

Parkinson, Christopher J.; Haynes, Richard; Birrell, Geoffrey W.; Chavchich, Marina; Mackenzie, Donna (Oxford Univ Press, 2019)

Objectives Drug resistance exists to all current and investigational antimalarial drug classes. Consequently, we have set out to develop chemically and mechanistically discrete antimalarials. Here we report on the development ...