Browsing Faculty of Health Sciences by Author "Zuma, Nonkululeko H."
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In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes
Aucamp, Janine; Zuma, Nonkululeko H.; N'Da, David D. (Elsevier, 2020)Leishmaniasis is a neglected tropical disease affecting thousands worldwide, especially in developing countries where it co-exists with malaria. Only a handful of drugs are clinically available to treat the disease, but ... -
Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues
Zuma, Nonkululeko H.; Smit, Frans J.; Aucamp, Janine; N'Da, David D.; Seldon, Ronnett (Elsevier, 2020)The emergence of drug-resistant tuberculosis (DR-TB) as well as the requirement for long, expensive and toxic drug regimens impede efforts to control and eliminate TB. Therefore, there’s a need for effective and affordable ... -
Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin
Zuma, Nonkululeko H.; Smit, Frans J.; N'Da, David D.; De Kock, Carmen; Combrinck, Jill (Elsevier, 2016)In an attempt to improve the efficacy and stability of current, clinically used artemisinins, a series non-hemiacetal ester derivatives of artemisinin were synthesized and evaluated for their in vitro antiplasmodial and ... -
Synthesis and in vitro antileishmanial efficacy of novel quinazolinone derivatives
Prinsloo, Izak F.; Zuma, Nonkululeko H.; Aucamp, Janine; N'Da, David D. (Wiley, 2020)Currently available drugs being used to treat leishmaniasis have several shortcomings, including high toxicity, drug administration that requires hospitalization, and the emergence of parasite resistance against clinically ... -
Synthesis and in vitro Leishmania promastigote growth inhibition efficacy of novel 4(3H)-quinazolinone derivatives
Ralph, Greg L.; Zuma, Nonkululeko H.; Aucamp, Janine; N'Da, David D. (ARKAT USA, 2020)Molecular hybridization is an increasingly important strategy in rational drug design and development. A series of novel quinazolinone-triazole hybrids have been synthesized and their antileishmanial activity investigat ...