Browsing Faculty of Health Sciences by Author "Wiesner, Lubbe"
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Accumulation of TB-active compounds in murine organs relevant to infection by mycobacterium tuberculosis
Tanner, Lloyd; Haynes, Richard K.; Wiesner, Lubbe (Frontiers Media, 2020)Tuberculosis (TB), the leading cause of death due to an infectious agent, requires prolonged and costly drug treatments. With the rise in incidence of MDR and XDR TB, newer more efficacious treatments which are better ... -
Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria
Du Plessis, Lissinda H.; Helena, Chrizaan; Van Huyssteen, Este; Kotzé, Awie F.; Wiesner, Lubbe (Wiley, 2014)Objectives Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the treatment and chemoprophylaxis of malaria. However, it has low solubility in water, a long elimination half-life (4 days), and is ... -
The in vitro and in vivo effects of hypoxis hemerocallidea on indinavir pharmacokinetics: modulation of efflux
Havenga, Kaylee; Steyn, Dewald; Hamman, Josias; Abay, Efrem; Wiesner, Lubbe; Viljoen, Alvaro (Thieme, 2018)(African potato) is a popular medicinal plant that has been used traditionally for the treatment of various disorders. Some HIV/AIDS patients use this traditional medicine together with their antiretroviral therapy. This ... -
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy
Aminake, Makoah N.; Grobler, Anne; Kumar, Vipan; Hans, Renate; Wiesner, Lubbe (Elsevier, 2012)Malaria and HIV are among the most important global health problems of our time and together are responsible for approximately 3 million deaths annually. These two diseases overlap in many regions of the world including ...