Now showing items 1-6 of 6

    • 99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles 

      Mandiwana, Vusani; Grobler, Anne; Zeevaart, Jan Rijn; Kalombo, Lonji (Elsevier, 2018)
      The aim of this study was to establish the in vivo uptake and tissue distribution of 99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive 99mTc-MDP encapsulated into SLNs was administered ...
    • Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration 

      Hayeshi, Rose; Kalombo, Lonji; Ramalapa, Bathabile; Semete, Boitumelo; Booysen, Laetitia; Swai, Hulda S.; Hayeshi, Rose; Kalombo, Lonji; Ramalapa, Bathabile; Semete, Boitumelo; Booysen, Laetitia; Swai, Hulda S. (Elsevier, 2012)
      The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study ...
    • The fabrication and characterization of a PLGA nanoparticle–Pheroid® combined drug delivery system 

      Chelopo, Madichaba P.; Grobler, Anne; Hayeshi, Rose; Kalombo, Lonji; Wesley-Smith, James (Springer, 2017)
      The combination of polymeric nanoparticles (NPs) as a core and lipid vesicles as a shell has emerged to be a robust and promising drug delivery strategy. This study explores the development of a novel combined delivery ...
    • In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems 

      Semete, Boitumelo; Booysen, Laetitia; Lemmer, Yolandy; Kalombo, Lonji; Katata, Lebogang; Verschoor, Jan; Swai, Hulda S.; Semete, Boitumelo; Booysen, Laetitia; Lemmer, Yolandy; Kalombo, Lonji; Katata, Lebogang; Verschoor, Jan; Swai, Hulda S. (Elsevier, 2010)
      The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some ...
    • Permeation of PLGA nanoparticles across different in vitro models 

      Nkabinde, Lindiwe A.; Hamman, Josias H.; Shoba-Zikhali, Lungile N.N.; Semete-Makokotlela, Boitumelo; Kalombo, Lonji (Bentham Science, 2012)
      Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance ...
    • Samarium oxide as a radiotracer to evaluate the in vivo biodistribution of PLGA nanoparticles 

      Mandiwana, Vusani; Grobler, Anne; Zeevaart, Jan Rijn; Kalombo, Lonji; Venter, Kobus (Springer, 2015)
      Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim of ...