Browsing Faculty of Health Sciences by Author "Emsley, Robin"
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Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
Möller, Marisa; Du Preez, Jan L.; Harvey, Brian H.; Emsley, Robin (Elsevier, 2011)Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR ... -
The nature of relapse in schizophrenia
Emsley, Robin; Harvey, Brian H.; Chiliza, Bonginkosi; Asmal, Laila (BioMed Central, 2013)Background: Multiple relapses characterise the course of illness in most patients with schizophrenia, yet the nature of these episodes has not been extensively researched and clinicians may not always be aware of important ... -
A randomized, controlled trial of omega-3 fatty acids plus an antioxidant for relapse prevention after antipsychotic discontinuation in first-episode schizophrenia
Emsley, Robin; Harvey, Brian H.; Chiliza, Bonginkosi; Asmal, Laila; Du Plessis, Stefan (Elsevier, 2014)Background: While antipsychotics are effective in the maintenance treatment of schizophrenia they have safety and tolerability risks. We investigated whether a combination of omega-3 polyunsaturated fatty acids (ω−3 ... -
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment
Möller, Marisa; Du Preez, Jan L.; Harvey, Brian H.; Emsley, Robin (Elsevier, 2012)Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium requires further study. Altered tryptophan metabolism has been described in schizophrenia, possibly linked to ... -
Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
Möller, Marisa; Du Preez, Jan L.; Viljoen, Francois P.; Harvey, Brian H.; Berk, Michael; Emsley, Robin (Elsevier, 2013)Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine release . N-acetyl cysteine ...