Browsing Faculty of Health Sciences by Author "De Kock, Carmen"
Now showing items 1-5 of 5
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Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin
Zuma, Nonkululeko H.; Smit, Frans J.; N'Da, David D.; De Kock, Carmen; Combrinck, Jill (Elsevier, 2016)In an attempt to improve the efficacy and stability of current, clinically used artemisinins, a series non-hemiacetal ester derivatives of artemisinin were synthesized and evaluated for their in vitro antiplasmodial and ... -
Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
Van Heerden, Lezanne; Cloete, Theunis T.; Breytenbach, J. Wilma; Breytenbach, Jaco C.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2012)Series of bisquinolines 4e15 and bispyrrolo[1,2a]quinoxalines 16e20 containing various polyamine linkers were synthesized. The aqueous solubility and distribution coefficient were experimentally determined. The compounds ... -
Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin
Cloete, Theunis T.; Breytenbach, J. Wilma; Breytenbach, Jaco C.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2012)In this study, a series of 11 10-aminoethylether derivatives of artemisinin were synthesised and their antimalarial activity against both the chloroquine sensitive (D10) and resistant (Dd2) strains of Plasmodium falciparum ... -
Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids
Pretorius, Stefan I.; Breytenbach, Wilma J.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2013)The aim of this study was to synthesize a series of quinoline–pyrimidine hybrids and to evaluate their in vitro antimalarial activity as well as cytotoxicity. The hybrids were brought about in a two-step nucleophilic s ... -
Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisininetriazine hybrids and hybrid-dimers
Cloete, Theunis T.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2014)A series of artemisininetriazine hybrids and hybrid-dimers were synthesized and their in vitro antimalarial activity against the chloroquine sensitive (CQS), the gametocytocidal (NF54) and the choroquine resistant (CQR) ...