Browsing Faculty of Health Sciences by Author "De Brouwer, Geoffrey"
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A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forward
De Brouwer, Geoffrey; Fick, Arina; Harvey, Brian H.; Wolmarans, De Wet (Springer, 2019)Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety- and compulsive-like behaviors or anxiolytic and anticompulsive drug action. However, the test responds ... -
Large nest building and high marble-burying: two compulsive-like phenotypes expressed by deer mice (Peromyscus maniculatus bairdii) and their unique response to serotoninergic and dopamine modulating intervention
De Brouwer, Geoffrey; Fick, Arina; Lombaard, Ané; Harvey, Brian H.; Wolmarans, De Wet (Elsevier, 2020)This study aimed to further dissect the deer mouse (Peromyscus maniculatus bairdii) model of compulsive-like behavior with respect to two persistent-like behavioral phenotypes viz. large nest building (LNB) and high ... -
Naturalistic operant responses in deer mice (Peromyscus maniculatus bairdii) and its response to outcome manipulation and serotonergic intervention
De Brouwer, Geoffrey; Harvey, Brian H.; Wolmarans, De Wet (Wolters Kluwer, 2020)Investigating the motivational triggers underlying naturalistic compulsive-like behavior is generally regarded as challenging. To this extent, the current study aimed to establish a proof-of-concept for future investigation ...