Browsing Faculty of Health Sciences by Author "Coertzen, Dina"
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Antimalarial N-1,N-3-dialkyldioxonaphthoimidazoliums: synthesis, biological activity, and structure-activity relationships
Ahenkorah, Stephen; Haynes, Richard K.; Coertzen, Dina; Tong, Jie Xin; Fridianto, Kevin (ACS, 2020)Here we report the nanomolar potencies of N1,N3-dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant Plasmodium falciparum. Activity was dependent on the presence of the fused quinone-imidazolium ... -
Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities
Beteck, Richard M.; Smit, Frans J.; Haynes, Richard K.; N'Da, David D.; Coertzen, Dina (Elsevier, 2016)As part of a programme aimed at identifying rational new triple drug combinations for treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one component, given that selected examples exhibit ...