Browsing Faculty of Health Sciences by Author "Cockeran, Marike"
Now showing items 1-20 of 25
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Anti-epileptic prescribing patterns in the South African private health sector (2008-2013)
Jacobs, Karen; Julyan, Marlene; Lubbe, Martie S.; Burger, Johanita R.; Cockeran, Marike (Taylor & Francis, 2016)Background: Little is known about longitudinal prescribing practices for anti-epileptic drugs (AEDs) in South Africa. The prescribing patterns and associated direct medicine costs of AEDs in the private ... -
Assessment of post-operative pain medication adherence after day case orthopaedic surgery: a prospective, cross-sectional study
Booysen, Vanessa; Burger, Johanita R.; Du Plessis, Jesslee M.; Cockeran, Marike (Elsevier, 2020)Background and aim Patients struggle to adhere to prescribed pain medication after surgery because of, inter alia, side effects, sleep disturbances and pain severity. This study aimed to determine the influence of various ... -
C679X loss-of-function PCSK9 variant lowers fasting glucose levels in a black South African population: a longitudinal study
Chikowore, Tinashe; Cockeran, Marike; Conradie, Karin R.; Van Zyl, Tertia (Elsevier, 2018)Aims To determine the longitudinal association of the loss-of-function (LOF) PCSK9 variants (C679X and A443T), proxies of PCSK9 inhibitor drugs, with LDL-C, fasting glucose and glycated hemoglobin. Methods We conducted ... -
Chronic depression symptoms desensitize renin activity to protect against volume-loading hypertension in Blacks: the SABPA study
De Vos, Arnoldeen C.; Malan, Leoné; Cockeran, Marike; Malan, Nicolaas T.; Seedat, Yackoob K. (Elsevier, 2018)Background Low-renin levels in Blacks have been associated with volume-loading hypertension (HT). Depression symptoms, frequently co-occurring with vascular dysregulation, might reflect a disturbed renin-angiotensin-ald ... -
Defensive coping and renovascular disease risk. Adrenal fatigue in a cohort of Africans and Caucasians: the SABPA study
De Kock, Andrea; Malan, Leoné; Hamer, Mark; Cockeran, Marike; Malan, Nico T. (Elsevier, 2015)Background: Defensive coping is an established cardiovascular risk factor in Africans. Additionally, chronic, excessive or inadequate hypothalamic pituitary adrenal axis (HPAA) stress responses could either increase or ... -
An elderly, urban population: their experiences and expectations of pharmaceutical services in community pharmacies
Janse van Rensburg, Alta; Kotzé, Irma; Lubbe, Martie Susanna; Cockeran, Marike (AOSIS, 2017)Objective: The aim of this study was to determine the pharmaceutical services experiences of an elderly, urban population in relation to their expectations in community pharmacy. Design: and setting: The study was a ... -
Ethnic disparity in defensive coping endothelial responses: the SABPA study
Scheepers, Jacobus De Wet; Malan, Leoné; De Kock, Andrea; Malan, Nicolaas Theodor; Cockeran, Marike; Von Känel, Roland (Elsevier, 2015)Objectives: Defensive coping (DefS) in Blacks has been associated with greater cardiovascular risk than in their White counterparts. We examined associations between endothelial function mental stress responses and markers ... -
Fibrosis and coronary perfusion: a cardiovascular disease risk in an African male cohort: the SABPA study
Jansen van Vuren, Esmé; Malan, Leoné; Cockeran, Marike; Scheepers, Jacobus D.; Oosthuizen, Woudri; Malan, Nicolaas T. (Taylor & Francis, 2016)Low-grade inflammation has been correlated with risk factors of cardiovascular diseases (CVD). Whether the pro-inflammatory and thrombotic ratio (fibrosis) may contribute to CVD is not known. We therefore aimed to assess ... -
How will South Africa’s mandatory salt reduction policy affect its salt iodisation programme? A cross-sectional analysis from the WHO-SAGE Wave 2 Salt & Tobacco study
Charlton, Karen; Ware, Lisa Jane; Baumgartner, Jeannine; Cockeran, Marike; Schutte, Aletta E. (BMJ Publishing Group, 2018)Objective The WHO’s global targets for non-communicable disease reduction recommend consumption of<5 g salt/day. In 2016, South Africa was the first country to legislate maximum salt levels in processed foods. South Africa’s ... -
Hypercoagulation and hyperkinetic blood pressure indicative of physiological loss-of-control despite behavioural control in Africans: the SABPA study
Scheepers, Jacobus De Wet; Malan, Leoné; De Kock, Andrea; Malan, Nicolaas Theodor; Cockeran, Marike; Von Känel, Roland (Taylor & Francis, 2016)Objectives: A dissociation between behavioural (in-control) and physiological parameters (indicating loss-of-control) is associated with cardiovascular risk in defensive coping (DefS) Africans. We evaluated relationships ... -
Hyperpulsatile pressure, systemic inflammation and cardiac stress are associated with cardiac wall remodeling in an African male cohort: the SABPA study
Jansen van Vuren, Esmé; Malan, Leoné; Von Känel, Roland; Cockeran, Marike; Malan, Nicolaas Theodor (Nature, 2016)Inflammation may contribute to an increase in cardiac wall stress through pathways related to cardiac remodeling. Cardiac remodeling is characterized by myocyte hypertrophy, myocyte death and modifications of the extracellular ... -
Hypertriglyceridaemia and the risk of pancreatitis six months post lopinavir/ritonavir initiation
Greffrath, Wilhelm P.; Du Plessis, Jesslee M.; Viljoen, Michelle; Cockeran, Marike (AOSIS, 2018)Background: Hypertriglyceridaemia (HTG) is an important risk factor for pancreatitis and cardiovascular disease (CVD), depending on severity. Hypertriglyceridaemia is common in human immunodeficiency virus (HIV) infection ... -
Infant development at the age of 6 months in relation to feeding practices, iron status, and growth in a peri-urban community of South Africa
Rothman, Marinel; Faber, Mieke; Covic, Namukolo; Matsungo, Tonderayi M.; Cockeran, Marike; Smuts, Cornelius M. (MDPI, 2018)Background: Evidence on the association between feeding practices, iron deficiency, anaemia, stunting, and impaired psychomotor development during infancy is limited. This study assessed the association between psychomotor ... -
Iodine status assessment in South African adults according to spot urinary iodine concentrations, prediction equations, and measured 24-h iodine excretion
Charlton, Karen E.; Ware, Lisa J.; Baumgartner, Jeannine; Cockeran, Marike; Schutte, Aletta E. (MDPI, 2018)The iodine status of populations is conventionally assessed using spot urinary samples to obtain a median urinary iodine concentration (UIC) value, which is assessed against standard reference cut-offs. The assumption that ... -
Lifestyle influences changes in fibrin clot properties over a 10-year period on a population level
Swanepoel, Albe Carina; De Lange-Loots, Zelda; Cockeran, Marike; Pieters, Marlien (Georg Thieme Verlag, 2022)Case–control and observational studies have provided a plausible mechanistic link between clot structure and thrombosis. We aimed to identify lifestyle, demographic, biochemical, and genetic factors that influence changes ... -
The long-term effects of methamphetamine exposure during pre-adolescence on depressive-like behaviour in a genetic animal model of depression
Mouton, Moné; Harvey, Brian H.; Cockeran, Marike; Brink, Christiaan B. (Springer, 2016)Methamphetamine (METH) is a psychostimulant and drug of abuse, commonly used early in life, including in childhood and adolescence. Adverse effects include psychosis, anxiety and mood disorders, as well as increased risk ... -
Medicine possession ratio as proxy for adherence to antiepileptic drugs: prevalence, associations, and cost implications
Jacobs, Karen; Julyan, Marlene; Lubbe, Martie S.; Burger, Johanita R.; Cockeran, Marike (Dovepress, 2016)Objective: To determine the adherence status to antiepileptic drugs (AEDs) among epilepsy patients; to observe the association between adherence status and age, sex, active ingredient prescribed, treatment period, and ... -
Methylphenidate and atomoxetine prescribing trends in children in the Western Cape Province of South Africa, 2005-2013
Joubert, Liezl; Burger, Johanita R.; Lubbe, Martie S.; Cockeran, Marike; Truter, Ilse (AOSIS, 2018)Background: There is paucity of data on methylphenidate and atomoxetine prescribing patterns in South African children. Aim: To describe the prescribing trends of these agents in children residing in the Western Cape ... -
Prediction of 24-hour sodium excretion from spot urine samples in South African adults: a comparison of four equations
Charlton, Karen; Cockeran, Marike; Schutte, Aletta E.; Ware, Lisa J.; Chidumwa, Glory (Nature, 2020)Repeated 24-hour urine collection is considered to be the gold standard for assessing salt intake. This is often impractical in large-population studies, especially in low–middle-income countries. Equations to estimate ... -
Prescribing patterns of non-steroidal anti-inflammatory drugs in chronic kidney disease patients in the South African private sector
Meuwesen, Willem P.; Du Plessis, Jesslee M.; Burger, Johanita R.; Lubbe, Martie S.; Cockeran, Marike (Springer, 2016)Background Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used pharmaceutical agents worldwide. NSAIDs are considered nephrotoxic and should therefore be used with caution or be avoided completely ...