Browsing Faculty of Health Sciences by Author "Chen, Fenghua"
Now showing items 1-6 of 6
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A critical role of mitochondria in BDNF-associated synaptic plasticity after one-week vortioxetine treatment
Chen, Fenghua; Wegener, Gregers; Danladi, Jibrin; Ardalan, Maryam; Elfving, Betina (Oxford Univ Press, 2018)Background Preclinical studies have indicated that antidepressant effect of vortioxetine involves increased synaptic plasticity and promotion of spine maturation. Mitochondria dysfunction may contribute to the pathophysiological ... -
Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment
Chen, Fenghua; Wegener, Gregers; Madsen, Torsten M.; Nyengaard, Jens R. (Wiley, 2013)Depressive disorders and the treatment thereof have been associated with a number of neuroplastic events, such as neurogenesis and synaptic remodeling in discrete areas of the brain. The associations of these events in ... -
A new efficient method for synaptic vesicle quantification reveals differences between medial prefrontal cortex perforated and nonperforated synapses
Nava, Nicoletta; Wegener, Gregers; Chen, Fenghua; Popoli, Maurizio; Randel Nyengaard, Jens (Wiley, 2014)Communication between neurons is mediated by the release of neurotransmitter-containing vesicles from presynaptic terminals. Quantitative characterization of synaptic vesicles can be highly valuable for understanding ... -
Quantitative hippocampal structural changes following elctroconvulsive seizure treatment in a rat model of depression
Kaae, Susanne S.; Wegener, Gregers; Chen, Fenghua; Madsen, Torsten M.; Nyengaard, Jens R. (Wiley, 2012)Objective: The pathophysiology of depression and the effects of antidepressant treatment are hypothesized to be related to hippocampal structural changes. This study aims to investigate the effect of electroconvulsive ... -
Structural plasticity and molecular markers in hippocampus of male rats after acute stress
Chen, Fenghua; Wegener, Gregers; Polsinelli, Benadetta; Nava, Nicoletta; Treccani, Giulia (Elsevier, 2020)Stress plays a crucial role in the pathogenesis of psychiatric disorders and affects neuronal plasticity in different brain regions. We have previously found that acute foot-shock (FS) stress elicits fast and long-lasting ... -
Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus
Chen, Fenghua; Wegener, Gregers; Du Jardin, Kristian Gaarn; Waller, Jessica A.; Sanchez, Connie (Elsevier, 2016)Preclinical studies reveal that the multimodal antidepressant vortioxetine enhances long-term potentiation and dendritic branching compared to a selective serotonin reuptake inhibitor (SSRI). In the present study, we ...