Browsing Faculty of Health Sciences by Author "Calitz, Carlemi"
Now showing items 1-7 of 7
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Cell-free DNA in a three-dimensional spheroid cell culture model: a preliminary study
Aucamp, Janine; Calitz, Carlemi; Bronkhorst, Abel J.; Hamman, Sias; Gouws, Chrisna; Pretorius, Piet J. (Elsevier, 2017)Background Investigating the biological functions of cell-free DNA (cfDNA) is limited by the interference of vast numbers of putative sources and causes of DNA release into circulation. Utilization of three-dimensional ... -
Characterization of an alginate encapsulated LS180 spheroid model for anti-colorectal cancer compound screening
Smit, Tanya; Calitz, Carlemi; Willers, Clarissa; Svitina, Hanna; Hamman, Josias; Gouws, Chrisna; Wrzesinski, Krzysztof (ACS, 2020)Colorectal cancer is one of the leading causes of cancer-related deaths. A main problem for its treatment is resistance to chemotherapy, requiring the development of new drugs. The success rate of new candidate cancer drugs ... -
Herb-drug pharmacokinetic interactions: transport and metabolism of indinavir in the presence of selected herbal products
Calitz, Carlemi; Gouws, Chrisna; Viljoen, Joe; Steenekamp, Jan; Hamman, Josias (MDPI, 2015)Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions ... -
Herbal hepatotoxicity: current status, examples, and challenges
Calitz, Carlemi; Du Plessis, Lissinda; Gouws, Chrisna; Steyn, Dewald; Steenekamp, Jan; Muller, Christo; Hamman, Sias (Taylor & Francis, 2015)Introduction: Herbal medicines have commonly been considered safe by the general public due to their natural origin and long history of traditional uses. In contrast to this belief, many plants produce toxic substances as ... -
Impact of traditional African medicine on drug metabolism and transport
Calitz, Carlemi; Steenekamp, Jan H.; Steyn, Johan D.; Gouws, Chrisna; Viljoen, Joe M.; Hamman, Josias H. (Taylor & Francis, 2014)Introduction: Africa is a continent of rich plant biodiversity with many indigenous plants having a long history of being used for medicinal purposes. A considerable number of patients consult traditional healers in ... -
Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective
Calitz, Carlemi; Hamman, Josias H.; Gouws, Chrisna; Fey, Stephen J.; Wrzesinski, Krzysztof (Taylor & Francis, 2018)The liver is a vital organ fulfilling a central role in over 500 major metabolic functions, including serving as the most essential site for drug biotransformation. Dysfunction of the drug biotransformation processes may ... -
Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short-term exposure to two-dimensional and three-dimensional spheroid cell cultures
Calitz, Carlemi; Hamman, Josias H.; Gouws, Chrisna; Viljoen, Alvaro M.; Fey, Stephen J. (Taylor & Francis, 2018)Xysmalobium undulatum (Uzara) is one of the most widely used indigenous traditional herbal remedies in Southern Africa. Commercially available Uzara plant material was used to prepare a crude aqueous extract, of which the ...