Browsing Faculty of Health Sciences by Author "Berk, Michael"
Now showing items 1-6 of 6
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Effect of chronic N-acetyl cystine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum
Harvey, Brian H.; Joubert, Charise; Du Preez, Jan L.; Berk, Michael (Springer, 2008)Antioxidants have possible therapeutic value in neurodegenerative disorders, although they may have pro-oxidant effects under certain conditions. Glutathione (GSH) is a key free radical scavenger. N-acetylcysteine (NAC) ... -
Ketamine and rapidly acting antidepressants: breaking the speed of sound or light?
Berk, Michael; Harvey, Brian H.; Loo, Collen; Davey, Christopher G. (Sage, 2018)There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key ... -
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
Möller, Marisa; Du Preez, Jan L.; Viljoen, Francois P.; Harvey, Brian H.; Berk, Michael (Springer, 2013)Schizophrenia is causally associated with early-life environmental stress, implicating oxidative stress in its pathophysiology. N-acetyl cysteine (NAC), a glutathione precursor and antioxidant, is emerging as a useful ... -
Neuroprogression in schizophrenia: pathways underpinning clinical staging and therapeutic corollaries
Davis, Justin; Harvey, Brian H.; Moylan, Steven; Maes, Michael; Berk, Michael (Sage, 2014)Objective: Whilst dopaminergic dysfunction remains a necessary component involved in the pathogenesis of schizophrenia, our current pharmacological armoury of dopamine antagonists does little to control the negative ... -
Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
Möller, Marisa; Du Preez, Jan L.; Viljoen, Francois P.; Harvey, Brian H.; Berk, Michael; Emsley, Robin (Elsevier, 2013)Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine release . N-acetyl cysteine ... -
Studies on haloperidol and adjunctive alpha-mangostin or raw Garcinia Mangostana Linn pericarp on bio-behavioral markers in an immune-inflammatory model of schizophrenia in male rats
Lotter, Jana; Möller, Marisa; Harvey, Brian H.; Dean, Olivia; Berk, Michael (Frontiers Media, 2020)The nematicidal activity of crudely milled powders of stems, leaves, and bulbs of Cassia abbreviata, Cissus cactiformis, Euphorbia ingens, Ipomoea kituiensis, Synadenium cupulare, Senna petersiana, Urigenia sanguinea, ...