Browsing Faculty of Health Sciences by Author "10061533 - Mienie, Lodewyk Jacobus"
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Die identifisering van fenielbottersuur aromatiese metaboliete in die urien van die blou-aap
Van der Linde, Wilhelmina J.; Mienie, Lodewyk J.; Bergh, Jacobus J.; Van der Walt, Mietha M.; Terre'Blanche, Gisella (Suid-Afrikaanse Akademie vir Wetenskap en Kuns, 2018)Phenylbutyrate (PBA) is used as treatment of urea cycle disorders and as an alternative treatment option for adrenoleykodystrophy, has neuroprotective effects and provides protection against oxidative stress. Known ... -
Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate
Viljoen, Jacques; Bergh, Jacobus J.; Mienie, Lodewyk J.; Terre'Blanche, Gisella; Kotzé, Herculaas F. (Springer, 2012)Valproate administration increases the level of the inhibitory transmitter, glycine, in the urine and plasma of patients and experimental animals. Nonketotic hyperglycinemia (NKH), an autosomal recessive disorder of ... -
The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time
Terre'Blanche, Gisella; Heyer, Nicolette; Bergh, Jacobus J.; Mienie, Lodewyk J.; Harvey, Brian H.; Van der Schyf, Cornelius J. (Springer, 2011)Exposure to the industrial solvent, styrene, induces locomotor and cognitive dysfunction in rats, and parkinsonian-like manifestations in man. The antipsychotic, haloperidol (HP), well known to induce striatal toxicity in ... -
Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid: a case report
Terre'Blanche, Gisella; Van der Walt, Mietha M.; Bergh, Jacobus J.; Mienie, Lodewyk J. (BioMed Central, 2011)This is a case report of adrenomyeloneuropathy (AMN), the adult variant of adrenoleukodystryphy (ALD). The diagnoses in the patient, aged 34, was confirmed via increased serum very long chain fatty acid concentration (VLCFA). ...