Browsing Faculty of Health Sciences by Title
Now showing items 21-40 of 2377
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68Ga-NOTA-functionalized ubiquicidin: cytotoxicity, biodistribution, radiation dosimetry, and first-in-human PET/CT imaging of infections
(Society of Nuclear Medicine and Molecular Imaging, 2018)Ubiquicidin is an antimicrobial peptide with great potential for nuclear imaging of infectious diseases, as its cationic-rich fragment TGRAKRRMQYNRR (UBI) has been functionalized with NOTA to allow complexation to 68Ga ... -
8-(3-phenylpropyl)-1,3,7-triethylxanthine is a synthetic caffeine substitute with stronger metabolic modulator activity
(Elsevier, 2018)Caffeine is one of the most worldwide consumed methylxanthines. It is well-known for its thermogenic and cell metabolism modulating effects. Based on methylxanthines' chemical structure, 8-(3-phenylpropyl)-1,3,7-triethylxanthine ... -
8-Aryl- and alkyloxycaffeine analogues as inhibitors of monoamine oxidase
(Elsevier, 2011)Recently it was reported that a series of 8-benzyloxycaffeine analogues are potent reversible inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to discover additional C8 oxy substituents of caffeine that ... -
8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA study
(Taylor & Francis, 2014)Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study ... -
99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles
(Elsevier, 2018)The aim of this study was to establish the in vivo uptake and tissue distribution of 99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive 99mTc-MDP encapsulated into SLNs was administered ... -
A biomarker of tissue damage, lactate dehydrogenase, is associated with fibulin-1 and oxidative stress in blacks: the SAfrEIC study
(Taylor & Francis Ltd, 2016)Context: Extracellular matrix (ECM) remodeling and oxidative stress is present in hypertension and associated arterial stiffness, but little is known on the physiological link among lactate dehydrogenase (LDH), fibulin-1, ... -
A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension
(Elsevier Science Inc, 2016)Elevated blood pressure is the strongest modifiable risk factor for cardiovascular disease worldwide. Despite extensive knowledge about ways to prevent as well as to treat hypertension, the global incidence and prevalence ... -
A century of trends in adult human height
(eLife Sciences Publications Ltd, 2016)Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height ... -
A community ''Hub'' network intervention for HIV stigma reduction: a case study
(Elsevier, 2016)We describe the implementation of a community “hub” network intervention to reduce HIV stigma in the Tlokwe Municipality, North West Province, South Africa. A holistic case study design was used, focusing on community ... -
A dose-response crossover iodine balance study to determine iodine requirements in early infancy
(American Society for Nutrition, 2016)Background: Optimal iodine intake during infancy is critical for brain development, but no estimated average requirement (EAR) is available for this age group. Objective: We measured daily iodine intake, excretion, and ... -
A HIV stigma reduction intervention for people living with HIV and their families
(Elsevier, 2016)Background The diagnosis of HIV is life-changing that requires people not only to deal with the disease but also to cope with the stigma attached to HIV. People living with HIV (PLWH) as well as their close family members ... -
A supervision tool to guide postgraduate students during research supervision
(Unisa Press Host: Dept Social Work, UJ, 2015)It is not uncommon for postgraduate students to postpone or terminate their studies due to emotional and/or academic reasons. The purpose of this research–based article is to propose a specific supervision tool ... -
A synthesis of homelessness in South Africa: a rapid critical appraisal
(Taylor & Francis, 2016)Homelessness in South Africa requires collaborative research. Social, political, cultural and economic factors that cause homelessness must be considered to develop a common definition and understanding of homelessness. ... -
Aanmelding van seksuele misbruik deur adolessente
(Department of Social Work, University of Stellenbosch, 2011)There is a high incidence of sexual abuse of adolescents in South Africa. Despite this, only a small number of sexual abuse cases are reported immediately. The main purpose of this research was to investigate the reasons ... -
Aard van neuro-motoriese inperkings by 7-en 8-jarige leerders met leerhindernisse
(2014)This study aimed to determine the extent of neuro-motor impairments in 7 to 8 year-old children with barriers to learning and the possible relationship of such impairment to specific learning areas. ... -
Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
(Elsevier, 2019)Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence ... -
Absorption of the novel artemisinin derivatives artemisone and artemiside: potential application of Pheroid™ technology
(Elsevier, 2011)Artemisinins have low aqueous solubility that results in poor and erratic absorption upon oral administration. The poor solubility and erratic absorption usually translate to low bioavailability. Artemisinin-based monotherapy ... -
Absorptive and secretory transport of selected artemisinin derivatives across Caco-2 cell monolayers
(Bentham Science, 2018)Background: Malaria continues to be a major health concern and affects more than 200 million people a year. Drugs currently used for treatment of malaria are increasingly rendered ineffectual by the ongoing emergence of ... -
Accelerated nutrition transition in the North West Province of South Africa: results from the Prospective Urban and Rural Epidemiology (PURE-NWP-SA) cohort study, 2005 to 2010
(Cambridge Univ Press, 2018)Objective: South Africa (SA) is in the midst of a health transition characterized by a quadruple burden of diseases and a nutrition transition. The existing nutrition transition in SA, accompanied by the coexistence of ...