Browsing Faculty of Health Sciences by Title
Now showing items 840-859 of 2385
-
The evaluation and quantification of respirable coal and silica dust concentrations: a task-based approach
(Taylor & Francis, 2014)Silicosis and coal worker's pneumoconiosis are serious occupational respiratory diseases associated with the coal mining industry and the inhalation of respirable dusts containing crystalline silica. The purpose of this ... -
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase
(Elsevier, 2017)The monoamine oxidase (MAO) enzymes are of considerable pharmacological interest and inhibitors are used in the clinic for the treatment of major depressive disorder and Parkinson's disease. A limited number of studies ... -
The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase
(Springer, 2020)Monoamine oxidase (MAO) is of much clinical relevance, and inhibitors of this enzyme are used in the treatment for neuropsychiatric and neurodegenerative disorders such as depression and Parkinson’s disease. The present ... -
Evaluation of 2-benzylidene-1-tetralone derivatives as antagonists of A1 and A2A adenosine receptors
(Wiley, 2018)Antagonists of the adenosine receptors (A1 and A2A) are thought to be beneficial in neurological disorders, such as Alzheimer's and Parkinson's disease. The aim of this study was to explore 2-benzylidene-1-tetralone ... -
Evaluation of a flexible NOTA-RGD kit solution using Gallium-68 from different 68Ge/ 68Ga-generators: pharmacokinetics and biodistribution in nonhuman primates and demonstration of solitary pulmonary nodule imaging in humans
(Springer, 2016)Purpose: Radiopharmaceuticals containing the motive tripeptide arginyl-glycyl-asparatic acid (RGD) are known to target ανβ3 integrins during tumor angiogenesis. A more generic kit radiolabeling procedure accommodating ... -
Evaluation of a Health Setting-Based Stigma Intervention in Five African Countries
(Mary Ann Liebert, Inc., 2009)The study aim is to explore the results of an HIV stigma intervention in five African health care settings. A case study approach was used. The intervention consisted of bringing together a team of approximately 10 nurses ... -
Evaluation of a mass-media campaign to increase the awareness of the need to reduce discretionary salt use in the South African population
(MDPI, 2017)The South African strategic plan to reduce cardiovascular disease (CVD) includes reducing population salt intake to less than 5 g/day. A mass media campaign was undertaken to increase public awareness of the association ... -
The evaluation of an equine–assisted therapy programme with a group of boys in a youth care facility
(Taylor & Francis, 2015)The goal of this study was to evaluate the efficacy of an equine-assisted therapy programme aimed at improving the psychological well-being of boys in a custodial school of industry. Participants were 39 boys who live in ... -
Evaluation of community-based growth monitoring in rural districts of the Eastern Cape and KwaZulu-Natal provinces of South Africa
(MedPharm Publications, 2009)Background: The Health Systems Trust implemented a community-based growth-monitoring intervention project that fits into the Integrated Nutrition Programme focus areas and commissioned an evaluation of this project. ... -
Evaluation of emissions and exposures at workplaces using desktop 3-dimensional printers
(Elsevier, 2019)There is a paucity of data on additive manufacturing process emissions and personal exposures in real-world workplaces. Hence, we evaluated atmospheres in four workplaces utilizing desktop “3-dimensional” (3-d) printers ... -
The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs
(Elsevier, 2018)Introduction The sensitivity of a given test to detect a treatment-induced effect in a variable of interest is intrinsically related to the variability of that variable observed without treatment and the number of ... -
Evaluation of isolated fractions of aloe vera gel materials on indinavir pharmacokinetics: in vitro and in vivo studies
(Bentham Science, 2016)Aloe vera is a plant with a long history of traditional medicinal use and is consumed in different products, sometimes in conjunction with prescribed medicines. A. vera gel has shown the ability to modulate drug absorption ... -
The evaluation of metal co-ordinating bis-thiosemicarbazones as potential anti-malarial agents
(Bentham Science, 2019)Background: The emergence of resistance to the artemisinins which are the current mainstays for antimalarial chemotheraphy has created an environment where the development of new drugs acting in a mechanistally discrete ... -
Evaluation of natural and synthetic 1,4-naphthoquinones as inhibitors of monoamine oxidase
(Wiley, 2016)Previous reports have documented that 1,4-naphtho- quinones act as inhibitors of the monoamine oxidase (MAO) enzymes. In particular, fractionation of the extracts of cured tobacco leafs has led to the charac- terization ... -
Evaluation of P-glycoprotein modulation by pharmaceutical excipients
(SAPJ, 2017)Modulation of P-glycoprotein (P-gp) may play a significant role in the systemic delivery of poorly bioavailable drugs e.g. anti-neoplastic drugs. Many compounds from different chemical classes, including pharmaceutical ... -
Evaluation of selected natural compounds as dual inhibitors of catechol-o-methyltransferase and monoamine oxidase
(Bentham Science, 2019)Background: The most effective symptomatic treatment of Parkinson’s disease remains the metabolic precursor of dopamine, L-dopa. To enhance the efficacy of L-dopa, it is often combined with inhibitors of the enzymes, ... -
An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase
(Elsevier, 2016)In a recent study we have shown that several indole-5,6-dicarbonitrile derivatives are potent inhibitors of human monoamine oxidase (MAO) A and B. To expand on these results and to further determine structure–activity ... -
The evaluation of the anti‐cancer drug elesclomol that forms a redox‐active copper chelate as a potential anti‐tubercular drug
(Wiley, 2019)The observations that the innate immune system employs copper toeliminate bacterial infection and that resistance to copper enhancesvirulence ofMycobacterium tuberculosis(Mtb) prompted us to exam-ine the effects the ... -
Evaluation of the cytotoxic properties, gene expression profiles and secondary signalling responses of cultured cells exposed to fumonisin B1, deoxynivalenol and zearalenone mycotoxins
(Springer, 2017)Mycotoxins are toxic secondary metabolites produced by a range of fungi and are common contaminants of agricultural crops. These toxins are chemically diverse and structurally stable, enabling them to enter the food ... -
Evaluation of the in vitro antimicrobial activity of a Pheroid®- entrapped plant extract against human pathogens
(Elsevier, 2019)This plant extract (PE) has proven activity against fungi affecting crops in South Africa. However, there is currently insufficient data on the activity of the PE against human pathogens. The general aim of this study ...