Browsing Faculty of Health Sciences by Title
Now showing items 550-569 of 2377
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Depressive symptoms and 24-hour ambulatory blood pressure in Africans: the SABPA study
(Hindawi, 2012)Disturbances in circadian rhythm might play a central role in the neurobiology of depression. We examined the association between depressive symptoms and 24-hour ambulatory BP in a sample of 405 (197 black and 208 Caucasian) ... -
Depressive symptoms and sub-clinical atherosclerosis in Africans: role of metabolic syndrome, inflammation and sympathoadrenal function
(Elsevier, 2011)Depressive symptoms have been consistently associated with sub-clinical atherosclerosis and future risk of coronary heart disease events. However, the pathways linking depression and coronary atherosclerosis are poorly ... -
Deriving an optimal threshold of waist circumference for detecting cardiometabolic risk in sub-Saharan Africa
(Nature, 2018)BACKGROUND: Waist circumference (WC) thresholds derived from western populations continue to be used in sub-Saharan Africa (SSA) despite increasing evidence of ethnic variation in the association between adiposity and ... -
Dermal exposure and changes in skin barrier function of base metal refinery workers co-exposed to cobalt and nickel
(The South African Society of Occupational Medicin, 2013)Refi nery workers are exposed to many metals, including cobalt and nickel, both of which are skin sensitisers, causing allergic contact dermatitis. Dermal exposure, and changes in skin barrier function [skin hydration, ... -
Dermal exposure sampling methods: an overview
(South African Society of Occupational Medicine, 2008) -
Describing a design thinking methodology to develop sustainable physical activity and nutrition interventions in low resourced settings
(Springer, 2018)The objective of the study is to describe how design thinking as a participatory process can be applied in determining how sustainable physical activity and nutrition interventions should be implemented in a low resourced ... -
Descriptive sensory analysis and consumer acceptability of lucerne (Medicago sativa L.)
(Emerald Group Publishing Limited, 2015)Abstract : "Purpose A lack of available literature exists about sensory data on lucerne (which is mainly used for animal feed) as an underutilised protein source for human consumption in South Africa (SA). Developing ... -
The design and evaluation of a hope enhancement programme for adults
(Taylor & Francis, 2008)The study evaluated the effectiveness of a hope enhancement programme for a group of adults and its impact on general psychological well-being. The intervention programme focused on participants' abilities to set feasible ... -
The design and evaluation of an l-dopa-lazabemide prodrug for the treatment of Parkinson’s disease
(MDPI, 2017)l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson’s disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and ... -
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents
(Elsevier, 2018)New 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives are proposed as dual-target-directed monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) inhibitors, as well as antioxidant agents, for the treatment of ... -
Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates
(RSC, 2016)The design, synthesis and biological evaluation of a series of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4- diamines is described. These compounds exhibited in vitro antiplasmodial activity in the low nanomolar range against ... -
Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase
(Springer, 2020)The most effective treatment of Parkinson’s disease is restoring central dopamine levels with levodopa, the metabolic precursor of dopamine. However, due to extensive peripheral metabolism by aromatic L-amino acid decarboxylase ... -
Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives
(Wiley, 2019)Tuberculosis is the deadliest infectious disease affecting humankind with a death toll of approximately 1.7 million people in 2016. The increasing prevalence of multidrug‐resistant strains of the causative pathogen, ... -
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles
(MDPI, 2019)New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B. The most important chiral ... -
A desire for weight loss in season increases disordered eating behaviour risk and energy deficiency in athletes
(MedPharm Publications, 2014)Objective: The objective was to explore eating behaviour, body image and energy status in female university team sport athletes. Design: This was a cross-sectional, descriptive study design. Setting: The setting was ... -
Determinants of childhood diarrhea among under-five year old children in Nigeria: a population-based study using the 2013 demographic and health survey data
(Turkish National Pediatric Society, 2018)The study aims to identify socioeconomic, demographic, environmental and child baseline factors associated with Childhood Diarrhea (CD) among under-five year old children in Nigeria. We utilized cross-sectional data from ... -
Determinants of plasma fibrin clot lysis measured using three different assays in healthy subject
(Elsevier, 2021)Introduction Several methods for measuring fibrinolytic capacity in plasma have been developed yielding frequently inconsistent results. We investigated which factors determine fibrinolytic capacity in three plasma-based ... -
Determinants of pre-lacteal feeding practices in urban and rural Nigeria; a population-based cross-sectional study using the 2013 Nigeria demographic and health survey data
(AJOL, 2017)Background: Prelacteal feeding (PLF) is a barrier to exclusive breast feeding. Objective: To determine factors associated with PLF in rural and urban Nigeria. Methods: We utilized data from the 2013 Nigerian Demographic ... -
Determinants of undernutrition prevalence in children aged 0–59 months in sub-Saharan Africa between 2000 and 2015. A report from the World Bank database
(Cambridge Univ Press, 2019)Objective To determine undernutrition prevalence in 0–59-month-old children and its determinants during the period 2000–2015 in sub-Saharan Africa. Design Ecological study of time series prevalence of undernutrition ... -
Determination of lovastatin, mevastatin, rosuvastatin and simvastatin with HPLC by means of gradient elution
(Avoxa, 2019)A novel HPLC method with UV detection was developed and validated in skin penetration (in vitro) studies to identify and quantify lovastatin, mevastatin, rosuvastatin and simvastatin. A Venusil XBP C18 (2), 150 x 4.6 mm, ...