Browsing Faculty of Health Sciences by Title
Now showing items 2181-2200 of 2386
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Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin
(Elsevier, 2012)In this study, a series of 11 10-aminoethylether derivatives of artemisinin were synthesised and their antimalarial activity against both the chloroquine sensitive (D10) and resistant (Dd2) strains of Plasmodium falciparum ... -
Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids
(Elsevier, 2013)The aim of this study was to synthesize a series of quinoline–pyrimidine hybrids and to evaluate their in vitro antimalarial activity as well as cytotoxicity. The hybrids were brought about in a two-step nucleophilic s ... -
Synthesis, complete 1H and 13C NMR assignment and crystal structure of novel epoxide derivatives of cytochalasin B
(University of Stellenbosch, 2008)Five novel epoxide derivatives of cytochalasin B were synthesized. Reaction of cytochalasin B with t-BHP and BuLi led to selective epoxidation of the C-21/22 double bond to give a single monoepoxide, while reaction with ... -
Synthesis, cytotoxicity and antimalarial activity of ferrocenyl amides of 4-aminoquinolines
(Thieme, 2010)Series of 4-aminoquinolines bearing an amino side chain linked to the ferrocene moiety through an amide bond were synthesized and evaluated for their antimalarial activity against both chloro-quine-sensitive (D10, CQ-S) ... -
Synthesis, evaluation and application of polycyclic fluorescent analogues as N-methyl-D-aspartate receptor and voltage gated calcium channel ligands
(Elsevier, 2011)A series of polycyclic fluorescent ligands were synthesised and evaluated in murine striatal synaptoneurosomes for N-methyl-D-aspartate receptor (NMDAR) mediated calcium flux inhibition and inhibition of calcium influx ... -
Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives
(Elsevier, 2018)Novel derivatives bearing a ferrocene attached via a piperazine linker to C-10 of the artemisinin nucleus were prepared from dihydroartemisinin and screened against chloroquine (CQ) sensitive NF54 and CQ resistant K1 and ... -
Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides
(Elsevier, 2014)A series of 4-aminoquinolinyl-chalcone amides 11–19 were synthesized through condensation of carboxylic acid-functionalized chalcone with aminoquinolines, using 1,10-carbonyldiimidazole as coupling agent. These compounds ... -
Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids
(Elsevier, 2011)Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids 9–14, which were then treated with oxalic acid to form oxalate salts (9a–14a). Compounds 9a, 10a, 12, 12a, and 14a showed comparable ... -
Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisininetriazine hybrids and hybrid-dimers
(Elsevier, 2014)A series of artemisininetriazine hybrids and hybrid-dimers were synthesized and their in vitro antimalarial activity against the chloroquine sensitive (CQS), the gametocytocidal (NF54) and the choroquine resistant (CQR) ... -
Synthesis, in vitro antiplasmodial and antiproliferative activities of a series of quinoline-ferrocene hybrids
(Springer, 2014)Series of quinoline–ferrocene hybrids containing various linkers were synthesized and evaluated for antimalarial and anticancer activities as well as cytotoxicity. The hybrids with rigid linkers were found to be ... -
Synthesis, in vitro evaluation, and 68Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection
(Wiley, 2017)Bacterial infections are a major concern in the human health sector due to poor diagnosis and development of multidrug-resistant strains. PET/CT provides a means for the non-invasive detection and localization of the ... -
Systematic evaluation of skeletal fractures caused by induction of electroconvulsive seizures in rat state a need for attention and refinement of the procedure
(Cambridge Univ Press, 2017)Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects ... -
A systematic review of counselling for HIV testing of pregnant women
(Blackwell Publishing Ltd, 2009)Background: Evidence-based strategies have made it possible to limit mother-to-child transmission of the HI-virus to a large extent and enable HIV-positive women to stay healthy for longer, provided their HIV status is ... -
A systematic review of reviews on effective home, family and community based interventions from low- and middle-in-come countries to inform the breastfeeding action plan for South Africa
(Karger, 2017)Background and objectives: South Africa has one of the lowest breastfeeding rates globally and an exclusive breastfeeding (EBF) rate below 10%. If South Africa is to to reach the World Health ... -
Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy
(Elsevier, 2019)There is an urgent need for therapies that could reduce the disease burden of preterm hypoxic-ischemic encephalopathy. Here, we evaluate the long-term effects of multipotent adult progenitor cells (MAPC) on long-term ... -
A tale of two systems-Nurses practice environment, well being, perceived quality of care and patient safety in private and public hospitals in South Africa: a questionnaire survey
(Elsevier, 2013)Objective: To examine the practice environment, nurse reported quality of care and patient safety, and nurse workforce outcomes in medical and surgical units in private and public hospitals in South Africa (SA), and determine ... -
Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?
(Wiley, 2017)Data from basic science experiments is overwhelmingly supportive of the causal role of immune-inflammatory response(s) at the core of atherosclerosis, and therefore, the theoretical potential to manipulate the inflammatory ... -
Teaching compassionate care to nursing students in a digital learning and teaching environment
(Elsevier, 2018)Background Healthcare that is technically excellent, but without compassion, fails to meet the expectations of patients. Ample evidence about teaching compassion to nursing students in classrooms exists; however, few ... -
Teaching employees money management skills and showing a profit in the process: Lessons from a financial literacy course
(Social Care Institute for Excellence, 2009) -
Team-based care for hypertensive patients is essential in low- and middle-income countries
(Wiley, 2019)In 2017, the World Hypertension League announced a new resource to support the development of hypertension training programmes for healthcare professionals.1 Three key elements are assessed with the tool: knowledge, ...