Browsing Faculty of Health Sciences by Author "10056173 - Malan, Nicolaas Theodor"
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Cohort profile: sympathetic activity and ambulatory blood pressure in Africans (SABPA) prospective cohort study
Malan, Leoné; Hamer, Mark; Steyn, Hendrik S.; Malan, Nicolaas T.; Frasure-Smith, Nancy (Oxford Univ Press, 2015)Adapting to an over–demanding stressful urban environment may exhaust the psychophysiological resources to cope with these demands, and lead to sympathetic nervous system dysfunction. The evidence that an urban–dwelling ... -
Comparison of central pressure estimates obtained from SphygmoCor, Omron HEM-9000AI and carotid applanation tonometry
Kips, Jan G.; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Fourie, Catharina M.; Malan, Leoné; Schutte, Rudolph (Lipppincott, Williams & Wilkins, 2011)Background: The Omron HEM-9000AI is the first automated tonometer to provide an estimate of central SBP (cSBP), which is considered to be more predictive of cardiovascular events than brachial pressure. However, considerable ... -
Comparison of Telomere Length in Black and White Teachers From South Africa: the Sympathetic Activity and Ambulatory Blood Pressure in Africans Study
Von Kanel, Roland; Malan, Nicolaas Theodor; Hamer, Mark; Malan, Leoné (Lippincott Williams & Wilkins, 2015)Objective: Telomere length is a marker of biological aging that has been linked to cardiovascular disease risk. The black South African population is witnessing a tremendous increase in the prevalence of cardiovascular ... -
Compromised bioavailable IGF-1 of black men relates favourably to ambulatory blood pressure: the SABPA study
Schutte, A.E.; Schutte, R.; Smith, W.; Huisman, H.W.; Mels, C.M.C.; Malan, L.; Fourie, C.M.T.; Malan, N.T.; Van Rooyen, J.M.; Kruger, R. (Elsevier, 2014)Objectives Insulin-like growth factor-1 (IGF-1) has potent endothelial-protective, anti-platelet and anti-thrombotic activities, and also exerts mitogenic and proliferatory actions on vascular smooth muscle cells. Conflicting ... -
Conventional and behavioral risk factors explain differences in sub-clinical vascular disease between black and Caucasian South Africans: the SABPA study
Hamer, M.; Malan, L.; Schutte, A.E.; Huisman, H.W.; Van Rooyen, J.M.; Schutte, Rudolph; Fourie, C.M.T.; Malan, N.T.; Seedat, Y.K. (Elsevier, 2011)Conventional and behavioral risk factors explain differences in sub-clinical vascular disease between black and Caucasian South Africans: The SABPA study Objectives: There is an emerging burden of cardiovascular disease ... -
Coping and metabolic syndrome indicators in urban black South African men: the SABPA study
Du Plessis, A.; Malan, L.; Malan, N.T. (Clinics Cardiv Publishing, 2010)Urbanisation is associated with obesity, hypertension anddevelopment of the metabolic syndrome (MS). We aimed toassess the use of different coping styles and their influenceon increases in MS indicators and target end-organ ... -
Coping facilitated troponin T increases and hypo-responsivity in the copeptin-HPA-axis during acute mental stress in a black cohort: the SABPA study
Myburgh, Catharina Elizabeth; Malan, Leoné; Möller, Marisa; Steyn, Faans; Malan, Nicolaas Theodor (Elsevier, 2019)Background Defensive coping (DefS) was associated with a vulnerable cardiovascular profile in blacks. The copeptin/vasopressin system is a manifestation of hypothalamic-pituitary-adrenal-axis activity and may act as an ... -
Coping with urbanization: a cardiometabolic risk? The THUSA study
Malan, Leoné; Malan, Nicolaas T.; Wissing, Maria P.; Seedat, Yackoob K. (Elsevier, 2008)An assessment of specific coping styles in rural-urban Africans is done to evaluate its contribution as cardiometabolic risk factor. In total, 608 apparently healthy Africans were included in a cross-sectional comparative ... -
Cornell product relates to albuminuria in hypertensive black adults independently of blood pressure: the SABPA study
Schutte, Rudolph; Huisman, Hugo W.; Ware, Lisa J.; Mels, Catherina M.C.; Smith, Wayne; Malan, Nicolaas T.; Malan, Leoné; Van Rooyen, Johannes M.; Fourie, Carla M.T.; Kruger, Ruan; Botha, Shani; Schutte, Aletta E. (Elsevier, 2015)Evidence of the relationship between left ventricular hypertrophy and urinary albumin excretion is contradictory and limited in black adults in whom hypertensive heart disease is common. We aimed to investigate the ... -
Correction to: Heart rate variability, the dynamic nature of the retinal microvasculature and cardiac stress: providing insight into the brain–retina–heart link: the SABPA study
Wentzel, Annemarie; Malan, Leoné; Von Känel, Roland; Smith, Wayne; Malan, Nicolaas T. (Springer, 2020)Correction to: Eye https://doi.org/10.1038/s41433-019-0515-y Since the online publication of this article, the authors have noticed that the conclusion to the abstract contains an error. The correct abstract conclusion ... -
Cortisol: brain-derived neurotrophic factor ratio associated with silent ischaemia in a black male cohort: the SABPA study
Schutte, Christiaan E.; Malan, Leoné; Scheepers, Jacobus D.; Oosthuizen, Woudri; Cockeran, Maricke; Malan, Nicolaas T. (SASA, 2016)Aim: Emotional distress has been associated with cardiovascular disease (CVD) in Africans. Cortisol and brain-derived neurotrophic factor (BDNF), as markers of emotional distress, increase cardiometabolic risk. We therefore ... -
The cost of coping: a cardio-neuro-metabolic risk for black South Africans?
Malan, Leoné; Malan, N.T.; Du Plessis, A.; Wissing, M.P.; Potgieter, J.C.; Seedat, Y.K. (Clinics Cardiv Publishing, 2010)Psychosocial stress is a contributing factor to cardiovascular disease. An important way of investigating the mechanisms underlying this association is acute psycho-physiological stress testing, involving measurement of ... -
Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: the SABPA study
Möller, Marisa; Malan, Leoné; Mels, Carina M.C.; Malan, Nico T.; Magnusson, Martin (Wiley, 2017)Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative ... -
Defensive coping and renovascular disease risk. Adrenal fatigue in a cohort of Africans and Caucasians: the SABPA study
De Kock, Andrea; Malan, Leoné; Hamer, Mark; Cockeran, Marike; Malan, Nico T. (Elsevier, 2015)Background: Defensive coping is an established cardiovascular risk factor in Africans. Additionally, chronic, excessive or inadequate hypothalamic pituitary adrenal axis (HPAA) stress responses could either increase or ... -
Defensive coping and subclinical vascular disease risk – associations with autonomic exhaustion in Africans and caucasians: the SABPA study
De Kock, A.; Malan, L.; Malan, N.T.; Hamer, M. (Elsevier, 2012)Objective The defensive active coping response is a recognised cardiovascular risk factor in Africans, especially in men. It is uncertain whether autonomic dysfunction might be the underlying cause. We therefore investigated ... -
Defensive coping facilitated a smaller cortisol-to-estradiol ratio and a higher hypertension risk: the SABPA study
Malan, Leoné; De Kock, Andrea; Hamer, Mark; Cockeran, Marike; Malan, Nicolaas Theodor (Taylor & Francis, 2018)Objectives: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It ... -
Defensive coping facilitates higher blood pressure and early sub–clinical structural vascular disease via alterations in heart rate variability: the SABPA study
Malan, L.; Hamer, M.; Schutte, R.; Van Rooyen, J.M.; Mels, C.M.; Fourie, C.M.T.; Uys, A.S.; Malan, N.T. (Elsevier, 2013)Objectives: Defensive coping (AC) responses in urban African males have been associated with vascular responsiveness, partly explaining autonomic nervous system dysfunction. We therefore aimed to assess whether AC responses ... -
Defensive coping, urbanization, and neuroendocrine function in Black Africans: the THUSA study
Malan, Leoné; Huisman, Hugo; Van Rooyen, Johannes; Schutte, Alta; Schutte, Rudolph; Potgieter, Johan; Wissing, Marié; Steyn, Faans; Malan, Nico (Wiley, 2012)Dissociation between b-adrenergic behavioral and physiological defensive active coping (AC) responses was associated with cardiometabolic risk in urban but not rural African males. Whether this is partly driven by underlying ... -
Depression symptoms facilitated fibrinolytic dysregulation and future coronary artery disease risk in a black male cohort: the sympathetic activity and ambulatory blood pressure in Africans study
Malan, Leoné; Mashele, Nyiko; Malan, Nicolaas T.; Harvey, Brian H.; Potgieter, Johan C.; Van Rooyen, Johannes M. (Wolters Kluwer, 2017)Background: Hypercoagulation is associated with coronary artery disease (CAD). Whether depression symptoms dysregulate inflammatory and hemostatic markers in an African cohort is not known; therefore, we assessed the ... -
Depressive symptoms and 24-hour ambulatory blood pressure in Africans: the SABPA study
Hamer, Mark; Harvey, Brian H.; Malan, Nico T.; Malan, Leoné; Frasure-Smith, Nancy (Hindawi, 2012)Disturbances in circadian rhythm might play a central role in the neurobiology of depression. We examined the association between depressive symptoms and 24-hour ambulatory BP in a sample of 405 (197 black and 208 Caucasian) ...