Browsing Faculty of Health Sciences by Title
Now showing items 1453-1472 of 2385
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Modulation of drug efflux by aloe materials: an in vitro investigation across rat intestinal tissue
(Medknow, 2013)Background: Clinically, significant herb-drug interactions have been previously documented and can be pharmacodynamic and/or pharmacokinetic in nature. Pharmacokinetic interactions have been attributed to induction or ... -
A molecular analysis of the GBA gene in Caucasian South Africans with Parkinson's disease
(Wiley, 2017)Background The molecular basis of Parkinson's disease in South African population groups remains elusive. To date, substitutions in the GBA gene are the most common large-effect genetic risk factor for Parkinson's disease. ... -
Molecular imaging of a zirconium-89 labeled antibody targeting Plasmodium falciparum–infected human erythrocytes
(Springer, 2020)Purpose Nuclear imaging is an important preclinical research tool to study infectious diseases in vivo and could be extended to investigate complex aspects of malaria infections. As such, we report for the first time ... -
Molecular phylogeny of the southern African endemic genus Sisyranthus (Apocynaceae: Asclepiadoideae-Ceropegieae)
(Elsevier, 2017)Sisyranthus E.Mey. species are placed in the tribe Ceropegieae, subtribe Anisotominae (Apocynaceae-Asclepiadoideae). Plants have their fertile parts hidden in the tube of the flowers, and are cryptic in both their habit ... -
Monitoring physical activity after a cardiovascular event: what is ‘fit’ for purpose?
(Sage, 2018)n the September issue of European Journal of Preventive Cardiology, Lavie and colleagues discussed how physical activity across the lifespan is a cost-effective strategy that must be implemented globally to improve overall ... -
Monitoring the South African population’s salt intake: spot urine v. 24 h urine
(Cambridge Univ Press, 2018)Objective The present study set out to determine whether morning spot urine samples can be used to monitor Na (and K) intake levels in South Africa, instead of the ‘gold standard’ 24 h urine sample. Design Participants ... -
Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma
(Thieme, 2011)The aim of this study was to synthesize a series of mono-, di- and trisubstituted derivatives of the human African trypanosomiasis drug eflornithine (alpha-difluoromethylornithine, DMFO, CAS 70052-12-9) to determine their ... -
Monoamine oxidase inhibition by C4-substituted phthalonitriles
(Elsevier, 2012)It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms ... -
Monoamine oxidase inhibition by Kavalactones from Kava (Piper Methysticum)
(Thieme, 2019)Monoamine oxidases (MAOs) are key metabolic enzymes for neurotransmitter and dietary amines and are targets for the treatment of neuropsychiatric and neurodegenerative disorders. This study examined the MAO inhibition ... -
Monoamine oxidase inhibition by selected anilide derivatives
(Elsevier, 2011)A series of anilide derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The most potent inhibitors among the derivatives that were initially evaluated were ... -
Monoamine oxidase inhibition by selected dye compounds
(Wiley, 2019)Monoamine oxidase (MAO) is an important drug target as the MAO isoforms play key roles in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as in neuropsychiatric diseases such as ... -
The monoamine oxidase inhibition properties of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one derivatives
(Springer, 2020)Quinazolinone compounds are of interest in medicinal chemistry since they display a wide range of biological properties. In the present study, a series of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one ... -
The monoamine oxidase inhibition properties of C6-mono- and N3/C6-disubstituted derivatives of 4(3H)-quinazolinone
(Elsevier, 2019)Parkinson’s disease is characterised by the death of the nigrostriatal neurons and depletion of striatal dopamine. The standard symptomatic therapy consists of dopamine replacement with l-dopa, the metabolic precursor of ... -
The monoamine oxidase inhibition properties of selected structural analogues of methylene blue
(Elsevier, 2017)The thionine dye, methylene blue (MB), is a potent inhibitor of monoamine oxidase (MAO) A, a property that may, at least in part, mediate its antidepressant effects in humans and animals. The central inhibition of MAO-A ... -
Monoamine oxidase inhibitory activities of heterocyclic chalcones
(Elsevier, 2015)Studies have shown that natural and synthetic chalcones (1,3-diphenyl-2-propen-1-ones) possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the present study is a report that a series of ... -
More good news about polymeric plant- and algae-derived biomaterials in drug delivery systems
(Bentham Science, 2014)Natural polymers are continuously investigated for use in pharmaceutical and tissue engineering applications due to the renewability of their supply. Besides the conventional use of natural materials in dosage form design ... -
Morning blood pressure surge in young black and white adults: the African-PREDICT study. Correction to this article: Journal of human hypertension (2019) 33:172. https://doi.org/10.1038/s41371-018-0121-7
(Nature, 2019)An exaggerated morning blood pressure surge (MBPS) has independent predictive value for cardiovascular mortality and is suggested to be prevalent in elderly hypertensive patients: men and white populations. To better ... -
Morning blood pressure surge relates to autonomic neural activity in young non-dipping adults: the African-PREDICT study
(Elsevier, 2019)Background It is well established that an exaggerated morning blood pressure surge (MBPS) is associated with an increased risk for cardiovascular disease development in hypertensive individuals. However, in non-dipping ... -
Morpho‐functional characteristics of bone marrow multipotent Mesenchymal Stromal Cells after activation or inhibition of epidermal growth factor and toll‐like receptors or treatment with DNA intercalator cisplatin
(Wiley, 2019)This study is aimed to reveal morphological and functional changes in multipotent mesenchymal stromal cells (MSCs) isolated from the rat bone marrow after: (i) activation of Toll‐like receptors (TLRs) with teichoic acid ... -
Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1 (PURE): an international, community-based cohort study
(Elsevier, 2019)Background The associations between the extent of forced expiratory volume in 1 s (FEV1) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations ...