Browsing Faculty of Health Sciences by Title

Now showing items 2381-2383 of 2383

α-Tetralone derivatives as inhibitors of monoamine oxidase

Legoabe, Lesetja J.; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2014)

In the present study, a series of fifteen a-tetralone (3,4-dihydro-2H-naphthalen-1-one) derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The a-tetralone ...
The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat

Uys, Madeleine M.; Harvey, Brian H.; Shahid, Mohammed; Sallinen, Jukka (Wolters Kluwer, 2017)

Depression involves deficits in monoaminergic neurotransmission. Differential roles for α2A, B and C subtypes of the α2-adrenoceptor (AR) are evident, with selective α2C-AR antagonists purported to have antidepressant and ...
The α2C-adrenoceptor antagonist, ORM-10921, has antipsychotic-like effects in social isolation reared rats and bolsters the response to haloperidol

Uys, Madeleine; Dreyer, Walter; Cockeran, Marike; Harvey, Brian H.; Shahid, Mohammed (Elsevier, 2016)

Early studies suggest that selective α2C-adrenoceptor (AR)-antagonism has anti-psychotic-like and pro-cognitive properties. However, this has not been demonstrated in an animal model of schizophrenia with a neurodevelopmental ...