Browsing Faculty of Health Sciences by Title
Now showing items 1965-1984 of 2377
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S-ketamine mediates its acute and sustained antidepressant-like activity through a 5-HT1B receptor dependent mechanism in a genetic rat model of depression
(Frontiers Media, 2018)Rationale: The mechanisms responsible for the unique antidepressant properties of ketamine have only been partly resolved. Recent preclinical reports implicate the neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] ... -
S-ketamine rapidly reverses synaptic and vascular deficits of hippocampus in genetic animal model of depression
(Oxford Univ Press, 2017)Background: The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce a rapid antidepressant effect within hours. In ... -
S-nitrosylation and attenuation of excessive calcium flux by pentacycloundecane derivatives
(Bentham Science, 2012)A novel series of polycyclic amines, containing nitrogen monoxide donating moieties, were synthesised and tested for calcium channel and N-methyl-D-aspartate receptor modulating activity. The synthesised compounds were ... -
The safety and efficacy of Meriva (R) and ginger extract combination in Pheroid (R) against lung cancer
(Elsevier, 2020)Lung cancer is the leading cause of cancer related deaths, globally, with poor survival profile. Cisplatin is frequently used in the treatment of many solid tumors including lung cancer despite its toxicity; ototoxicity, ... -
Safety pharmacology in and for Africa: establishment of the pre-clinical drug development platform
(Elsevier, 2018)Southern Africa (South Africa as well as neighboring countries) has not had an infrastructure for testing the safety of new drugs or other therapeutic entities, including plant-based or herbal treatments coming from the ... -
Safety pharmacology of herbal medicines in South Africa
(Elsevier, 2019)The use of herbal medicine for treating various ailments has a deep history in South African traditional medicine. South Africa has a rich floral biodiversity which has been exploited for centuries mainly for day-to-day ... -
Salt and potassium intake among adult Ghanaians: WHO-SAGE Ghana Wave 3
(BMC, 2020)Though Ghana has high hypertension prevalence, the country lacks current national salt consumption data required to build and enhance advocacy for salt reduction. We explored the characteristics of a randomly selected sub ... -
Salt use behaviours of Ghanaians and South Africans: a comparative study of knowledge, attitudes and practices
(MDPI, 2017)Salt consumption is high in Africa and the continent also shares the greatest burden of hypertension. This study examines salt-related knowledge, attitude and self-reported behaviours (KAB) amongst adults from two African ... -
Salutogenic versus Pathogenic metaphorical language usage in South Africa's National HIV/AIDS Education Policy
(North-West University, 2019)This study explored the use of metaphorical language in South Africa’s national HIV/AIDS education policy, and to what extent the metaphorical messages conveyed about HIV and AIDS in the policy are essentially health ... -
Samarium oxide as a radiotracer to evaluate the in vivo biodistribution of PLGA nanoparticles
(Springer, 2015)Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim of ... -
SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs
(Taylor & Francis, 2019)The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. ... -
The SASPER: a tool to assess student social workers performance during field placements
(Unisa Press, 2013) -
São Paulo call to action for the prevention and control of high blood pressure: 2020
(Wiley, 2019)Key Messages About 1/4th of adults have high blood pressure which is the single most important risk for death (including heart disease and stroke). There are effective policies that could facilitate people making healthy ... -
São Paulo call to action for the prevention and control of high blood pressure: 2020
(Wiley, 2019)About 1/4th of adults have high blood pressure which is the single most important risk for death (including heart disease and stroke). There are effective policies that could facilitate people making healthy choices to ... -
The schizophrenia and bipolar disorder associated BRD1 gene is regulated upon chronic restraint stress
(Elsevier, 2012)Recent genetic evidence has implicated the bromodomain containing 1 gene (BRD1) with brain development and susceptibility to Schizophrenia and Bipolar Disorder. The BRD1 protein, which is essential for acetylation of histone ... -
School environment, socioeconomic status and weight of children in Bloemfontein, South Africa
(2015)Background: The continued existence of undernutrition, associated with a steady increase in the "prevalence of overweight and obesity in children and adolescents, necessitates identification of" "factors contributing to ... -
School uniforms: tradition, benefit or predicament?
(Taylor & Francis, 2012)This article focuses on the controversies surrounding school uniforms. Roleplayers in this debate in South Africa are parents, learners and educators, and arguments centre on aspects such as identity, economy and the ... -
Secondary sexual characteristics of stunted and non-stunted Black South African Boys living in a township in the North West Province
(Sabinet, 2012)It is known that sexual maturation is dependent on genetic and environmental factors and socio-economic status. The purpose of this study was to describe secondary sexual characteristics of stunted and non-stunted black ... -
The SeDeM expert diagram system: its performance and predictability in direct compressible formulations containing novel excipients and different types of active ingredients
(Elsevier, 2017)The SeDeM Expert Diagram System is a galenic pre-formulation system, which evaluates the suitability of excipients and active pharmaceutical ingredients (API's) for direct compression into tablets as well as predicting ...