Browsing Faculty of Health Sciences by Title
Now showing items 289-308 of 2377
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C2-substituted quinazolinone derivatives exhibit A1 and/or A2A adenosine receptor affinities in the low micromolar range
(Elsevier, 2020)Antagonists of the adenosine receptors (A1 and A2A subtypes) are widely researched as potential drug candidates for their role in Parkinson’s disease-related cognitive deficits (A1 subtype), motor dysfunction (A2A subtype) ... -
C3 amino-substituted chalcone derivative with selective adenosine rA1 receptor affinity in the micromolar range
(Springer, 2020)To identify novel adenosine receptor (AR) ligands based on the chalcone scaffold, herein the synthesis, characterization and in vitro and in silico evaluation of 33 chalcones (15–36 and 37–41) and structurally related ... -
C6- and C7-substituted 3,4-dihydro-2(1H)-quinolinones as inhibitors of monoamine oxidase
(Thieme, 2017)Purpose Monoamine oxidase (MAO) inhibitors are considered to be useful therapeutic agents and isoform specific inhibitors are employed for the treatment of depression and Parkinson’s disease. MAO inhibitors are also under ... -
C679X loss-of-function PCSK9 variant lowers fasting glucose levels in a black South African population: a longitudinal study
(Elsevier, 2018)Aims To determine the longitudinal association of the loss-of-function (LOF) PCSK9 variants (C679X and A443T), proxies of PCSK9 inhibitor drugs, with LDL-C, fasting glucose and glycated hemoglobin. Methods We conducted ... -
Caffeine as a lead compound for the design of therapeutic agents for the treatment of Parkinson’s disease
(Bentham Science, 2015)The current pharmacological therapies for the treatment of Parkinson’s disease are mostly inadequate and recent, improved therapeutic agents are required. Two important molecular targets for the design of anti-parkinsonian ... -
Caffeine improves triathlon performance: a field study in males and females
(Human Kinetics, 2018)The ergogenic effect of caffeine on endurance exercise is commonly accepted. We aimed to elucidate realistically the effect of caffeine on triathlon event performance using a field study design, while allowing investigation ... -
A call for improved reporting on serious adverse events in clinical trials
(Wolters Kluwer, 2019)Following SPRINT (Systolic Blood Pressure Intervention Trial) [1], several investigations including systematic reviews and meta-analyses confirmed that reducing SBP to levels below 140 mmHg markedly reduces the risk of ... -
Can ambulatory blood pressure measurements substitute assessment of subclinical cardiovascular damage?
(Kluwer, 2012)Objective: We have previously demonstrated that markers of subclinical organ damage (SOD) improve cardiovascular risk prediction in healthy individuals. We wanted to investigate whether this additive effect of SOD was due ... -
Can South African biokineticists function as recreational therapists: a review of the minimum training standards relevant to each profession?
(Taylor & Francis, 2020)In South Africa, the profession of Recreational Therapy is recognized by neither the Health Professions Council South Africa (HPCSA) nor the Allied Health Professions Council of South Africa (AHPCSA). However, the South ... -
Can South African biokineticists function as recreational therapists: a review of the minimum training standards relevant to each profession?
(Taylor & Francis, 2020)In South Africa, the profession of Recreational Therapy is recognized by neither the Health Professions Council South Africa (HPCSA) nor the Allied Health Professions Council of South Africa (AHPCSA). However, the South ... -
Can South African biokineticists function as recreational therapists: a review of the minimum training standards relevant to each profession?
(Taylor & Francis, 2019)In South Africa, the profession of Recreational Therapy is recognized by neither the Health Professions Council South Africa (HPCSA) nor the Allied Health Professions Council of South Africa (AHPCSA). However, the South ... -
Cancer patients' ilness expierences during a group intervention
(PSYSSA, 2008) -
Cancer treatment in South Africa: a narrative literature review
(Taylor & Francis, 2012)Due to the advances in cancer treatment, there are a growing number of cancer survivors. Finishing treatment rarely indicates the end of the cancer experience. As a result, cancer management has shifted from an acute care ... -
A canning quality model for small white bean lines selected for breeding (Phaseolus vulgaris L.)
(Forum Press International, 2008) -
Capsaicin and piperine as functional excipients for improved drug delivery across nasal epithelial models
(Thieme, 2019)The fruit from various pepper plants has been employed for the seasoning of food, as perfuming agents, and also as traditional medicines. Phytochemicals isolated from different pepper species have been found to modulate ... -
Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists
(Elsevier, 2016)A novel series of carbamate substituted 2-amino-4,6-diphenylpyrimidines was evaluated as potential dual adenosine A1 and A2A receptor antagonists. The majority of the synthesised compounds exhibited promising dual affinities, ... -
Carbon-14 radiolabeling and in vivo biodistribution of a potential anti-TB compound
(Wiley, 2015)A potential anti-TB compound bearing a nitroimidazole moiety from iThemba Pharmaceuticals TB chemical library exhibits promising in vitro activity in the microplate almar blue assay (MABA) with a minimum inhibitory ... -
Carbon-14 radiolabelling and tissue distribution evaluation of a potential anti-TB compound
(Wiley, 2016)This paper describes a five-step synthesis of a carbon-14-labelled pyrazole compound (11). A total of 2.96 MBq of 11 was obtained with the specific activity of 2242.4 MBq/mmol. The radiochemical purity was >99%, and the ... -
Carbon‐14 radiolabeling and tissue distribution evaluation of MMV390048
(Wiley, 2016)The antimalarial compound MMV390048 ([14C]-11) was labeled with carbon-14 isotope via a 3-step synthesis. It was obtained in a 15.5% radiochemical overall yield from carbon-14 labeled methyl iodide with a radiochemical ... -
Cardiac
(Wiley, 2016)This chapter highlights various non-automated classical in vitro techniques used today to evaluate drug effects on cardiac electrophysiology. It then outlines a three-pronged preclinical initiative called the Comprehensive ...