Browsing Faculty of Health Sciences by Author "6d409ddf-9a12-4e61-9381-bad989e8e6eb"

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    • The effect of entrapment of a peptide in Pheroid® on pharmacokinetics and testosterone levels 

      Hayeshi, Rose; Erasmus, Linné; Scholtz, Liezl-Marie; Venter, Kobus; Bester, Cor; Fick, Antoinette; Leussa, Nyango-Nkeh Adrienne; Grobler, Anne (Elsevier, 2019)
      Goserelin is a peptide drug that suppresses levels of testosterone and oestradiol [1]. The current formulation is presented in a sustained-release depot with several approved indications such as treatment of endometriosis, ...

    • Establishment and characterization of allograft and xenograft cancer rodent models 

      Koatale, Palesa; Okem, Ambrose; Venter, Kobus; Fick, Antoinette; Bester, Cor; Hayeshi, Rose (Elsevier, 2019)
      To evaluate the efficacy of newly synthesized therapies prior to clinical trials, valid and true cancer models should be used [1]. For modelling cancer in vivo, transplantation of rodent (allograft) and human cancer ...

    • Evaluation of the oral delivery of a peptide with Pheroid® technology 

      Erasmus, Linné; Scholtz, Liezl-Marie; Venter, Kobus; Bester, Cor; Fick, Antoinette; Mabena, Jacob; Grobler, Anne; Hayeshi, Rose (Elsevier, 2019)
      Goserelin is a type of hormone therapy used in addition to standard adjuvant therapy. Currently, goserelin is only available as a slow releasing subcutaneous implant but this is an invasive and generally not well- tolerated ...