Browsing Faculty of Health Sciences by Author "38186d52-4395-4812-8ea8-736ee7068901"
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Considerations for an in vitro, cell-based testing platform for detection of adverse drug-induced inotropic effects in early drug development. Part 1: General considerations for development of novel testing platforms
Guth, Brian D.; Engwall, Michael; Eldridge, Sandy; Foley, C. Michael; Guo, Liang (Frontiers Media, 2019)Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted ... -
Considerations for an in vitro, cell-based testing platform for detection of drug-induced inotropic effects in early drug development. Part 2. Designing and fabricating microsystems for assaying cardiac contractility with physiological relevance using human iPSC-cardiomyocytes
Ribeiro, Alexandre J.S.; Guth, Brian D.; Engwall, Michael; Eldridge, Sandy; Foley, C. Michael (Frontiers Media, 2019)Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human ...