Browsing Faculty of Health Sciences by Author "10808932-ad7b-4050-acff-db40b7040b33"
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Drug bioavailability enhancing agents of natural origin (bioenhancers) that modulate drug membrane permeation and pre-systemic metabolism
Peterson, Bianca; Weyers, Morné; Steenekamp, Jan H.; Steyn, Johan D.; Gouws, Chrisna; Hamman, Josias H. (MDPI, 2019)Many new chemical entities are discovered with high therapeutic potential, however, many of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility and/or poor membrane permeation characteristics. ... -
A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model
Calitz, Carlemi; Hamman, Josias H.; Gouws, Chrisna; Wrzesinski, Krzysztof; Fey, Stephen J. (Elsevier, 2019)Ethnopharmacology relevance Traditional herbal medicines are utilized by 27 million South Africans. Xysmalobium undulatum (Uzara) is one of the most widely used traditional medicinal plants in Southern Africa. A false ...