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Uncovering the metabolic response of abalone (Haliotis midae) to environmental hypoxia through metabolomics
(Springer, 2018)
Introduction
Oxygen is essential for metabolic processes and in the absence thereof alternative metabolic pathways are required for energy production, as seen in marine invertebrates like abalone. Even though hypoxia has ...
The cross-tissue metabolic response of abalone (Haliotis midae) to functional hypoxia
(The Company of Biologists, 2018)
Functional hypoxia is a stress condition caused by the abalone itself as
a result of increased muscle activity, which generally necessitates the
employment of anaerobic metabolism if the activity is sustained for
prolonged ...
Metabolomics reveals the depletion of intracellular metabolites in HepG2 cells after treatment with gold nanoparticles
(Taylor & Francis, 2018)
Studies on the safety of gold nanoparticles (GNPs) are plentiful due to their successful application in drug delivery and treatment of diseases in trials. Cytotoxicity caused by GNPs has been studied on the physiological ...
Miniaturized 1H-NMR method for analyzing limited-quantity samples applied to a mouse model of Leigh disease
(Springer, 2018)
Introduction
The analysis of limited-quantity samples remains a challenge associated with mouse models, especially for multi-platform metabolomics studies. Although inherently insensitive, the highly specific characteristics ...
GC-MS-based urinary organic acid profiling reveals multiple dysregulated metabolic pathways following experimental acute alcohol consumption
(Nature, 2018)
Metabolomics studies of diseases associated with chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways. Moreover, the holistic approach of such studies gives insights into the ...
Mycobacterium tuberculosis curli pili (MTP) is associated with significant host metabolic pathways in an A549 epithelial cell infection model and contributes to the pathogenicity of Mycobacterium tuberculosis
(Springer, 2020)
Introduction
A clear understanding of the metabolome of Mycobacterium tuberculosis and its target host cell during infection is fundamental for the development of novel diagnostic tools, effective drugs and vaccines ...
Mycobacterium tuberculosis curli pili (MTP) is associated with significant host metabolic pathways in an A549 epithelial cell infection model and contributes to the pathogenicity of Mycobacterium tuberculosis
(Springer, 2020)
Introduction
A clear understanding of the metabolome of Mycobacterium tuberculosis and its target host cell during infection is fundamental for the development of novel diagnostic tools, effective drugs and vaccines ...
TB or not TB? Improving the understanding and diagnosis of tuberculosis through metabolomics
(Future Medicine, 2016)
“
...metabolomics has resulted in an exponential increase in the
number of newly identified tuberculosis biomarkers, which has not
only shed light on previously unknown disease mechanisms, but could
potentially ...
Metabolomics and personalized medicine
(Elsevier, 2016)
Current clinical practice strongly relies on the prognosis, diagnosis, and treatment of diseases using methods determined and averaged for the specific diseased cohort/population. Although this approach complies positively ...
Gas chromatography-mass spectrometry profiles of urinary organic acids in healthy captive cheetahs ( Acinonyx jubatus )
(Elsevier, 2017)
In captivity, cheetahs (Acinonyx jubatus) frequently suffer from several unusual chronic diseases that rarely occur in their free-ranging counterparts. In order to develop a better understanding of their metabolism and ...