Search
Now showing items 1-7 of 7
The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase
(Elsevier, 2015)
In the present study, series of eight sesamol (1,3-benzodioxol-5-ol) and eight benzodioxane (2,3-dihydro-1,4-benzodioxine) derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase ...
2-Acetylphenol analogs as potent reversible monoamine oxidase inhibitors
(Dove Press, 2015)
Based on a previous report that substituted 2-acetylphenols may be promising leads for the design of novel monoamine oxidase (MAO) inhibitors, a series of C5-substituted 2-acetylphenol analogs (15) and related compounds ...
Multifunctional enzyme inhibition for neuroprotection: a focus on MAO, NOS, and AChE inhibitors
(Elsevier, 2015)
Neurodegenerative disorders are known to be multifactorial in nature and current research focus has moved from a ‘one-drug-one-target approach’ to that of drugs which are able to act at various relevant biological targets. ...
The synthesis and evaluation of C7-substituted α-tetralone derivatives as inhibitors of monoamine oxidase
(Wiley, 2015)
Based on a previous report that α-tetralone (3,4-dihydro-2H-naphthalen-1-one) is a promising scaffold for the design of highly potent inhibitors of the enzyme, monoamine oxidase, the present study investigates the monoamine ...
Indanones as high-potency reversible inhibitors of monoamine oxidase
(Wiley, 2015)
Recent reports document that α-tetralone (3,4-dihydro-2H-naphthalen-1-one) is an appropriate scaffold for the design of high-potency monoamine oxidase (MAO) inhibitors. Based on the structural similarity between α-tetralone ...
Caffeine as a lead compound for the design of therapeutic agents for the treatment of Parkinson’s disease
(Bentham Science, 2015)
The current pharmacological therapies for the treatment of Parkinson’s disease are mostly inadequate and recent, improved therapeutic agents are required. Two important molecular targets for the design of anti-parkinsonian ...
Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives
(Elsevier, 2015)
Recent studies have found that phthalonitrile derivatives are remarkably potent inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to further determine the structure-activity relationships (SARs) for MAO ...