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dc.contributor.authorAndreassen, Monica
dc.contributor.authorVan den Berg, Johnnie
dc.contributor.authorRocca, Elena
dc.contributor.authorBøhn, Thomas
dc.contributor.authorWikmark, Odd-Gunnar
dc.date.accessioned2016-09-12T06:32:20Z
dc.date.available2016-09-12T06:32:20Z
dc.date.issued2015
dc.identifier.citationAndreassen, M. et al. 2015. Humoral and cellular immune responses in mice after airway administration of Bacillus thuringiensis Cry1Ab and MON810 cry1Ab–transgenic maize. Food and agricultural immunology, 26(4):521-537. [https://doi.org/10.1080/09540105.2014.988128]en_US
dc.identifier.issn0954-0105
dc.identifier.issn1465-3443 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/18629
dc.identifier.urihttps://doi.org/10.1080/09540105.2014.988128
dc.identifier.urihttp://www.tandfonline.com/doi/full/10.1080/09540105.2014.988128
dc.description.abstractGenetically modified (GM) crops may bring new proteins with immunogenic and allergenic properties into the food and feed chains. The most commonly grown GM maize, MON810, expresses a modified version of the insecticidal Cry1Ab protein originating in the soil bacterium Bacillus thuringiensis (Bt). Immune reactions following inhalation of pollen and debris from such plants have been scarcely studied. We exposed BALB/c mice to purified Cry1Ab proteins and Cry1Ab-containing MON810 plant materials by intranasal installation. No anti-Cry1Ab antibodies were detected following exposure to the plant materials. Exposure to purified Cry1Ab resulted in specific anti-Cry1Ab IgG1 and IgE production, indicating inherent immunogenicity and allergenicity. Mice exposed to leaf extracts from both MON810 and unmodified maize demonstrated influx of lymphocytes and eosinophils in the broncho-alveolar lavage, and increased cytokine release in mediastinal lymph node cells. The results indicate that the airway exposure to Cry1Ab proteins may be a route of practical relevanceen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectBacillus thuringiensisen_US
dc.subjectMON810en_US
dc.subjectCry1Aben_US
dc.subjectIgEen_US
dc.subjectairway allergyen_US
dc.subjectmouse modelsen_US
dc.titleHumoral and cellular immune responses in mice after airway administration of Bacillus thuringiensis Cry1Ab and MON810 cry1Ab–transgenic maizeen_US
dc.typeArticleen_US
dc.contributor.researchID12319724 - Van den Berg, Johann


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