Plasma clot lysis time and its association with cariovascular risk factors in black Africans
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Date
2012Author
De Lange, Zelda
Pieters, Marlien
Jerling, Johann C.
Kruger, Annamarie
Rijken, Dingeman C.
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Studies in populations of European descent show longer plasma clot lysis times (CLT) in patients with cardiovascular disease
(CVD) than in controls. No data are available on the association between CVD risk factors and fibrinolytic potential in black
Africans, a group undergoing rapid urbanisation with increased CVD prevalence. We investigated associations between
known CVD risk factors and CLT in black Africans and whether CLTs differ between rural and urban participants in light of
differences in CVD risk. Data from 1000 rural and 1000 urban apparently healthy black South Africans (35–60 years) were
cross-sectionally analysed. Increased PAI-1act, BMI, HbA1c, triglycerides, the metabolic syndrome, fibrinogen concentration,
CRP, female sex and positive HIV status were associated with increased CLTs, while habitual alcohol consumption
associated with decreased CLT. No differences in CLT were found between age and smoking categories, contraceptive use
or hyper- and normotensive participants. Urban women had longer CLT than rural women while no differences were
observed for men. CLT was associated with many known CVD risk factors in black Africans. Differences were however
observed, compared to data from populations of European descent available in the literature, suggesting possible ethnic
differences. The effect of urbanisation on CLT is influenced by traditional CVD risk factors and their prevalence in urban and
rural communities
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http://hdl.handle.net/10394/17479http://journals.plos.org/plosone/article/asset?id=10.1371%2Fjournal.pone.0048881.PDF
http://dx.doi.org/10.1371/journal.pone.0048881
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- Faculty of Health Sciences [2386]