dc.contributor.author | Möller, Marisa | |
dc.contributor.author | Du Preez, Jan L. | |
dc.contributor.author | Viljoen, Francois P. | |
dc.contributor.author | Harvey, Brian H. | |
dc.contributor.author | Berk, Michael | |
dc.date.accessioned | 2015-10-07T09:06:43Z | |
dc.date.available | 2015-10-07T09:06:43Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Möller, M. et al. 2013. N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats. Metabolic brain disease, 28:687-696. [https://doi.org/10.1007/s11011-013-9433-z] | en_US |
dc.identifier.issn | 0885-7490 | |
dc.identifier.issn | 1573-7365 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/14677 | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s11011-013-9433-z | |
dc.identifier.uri | https://doi.org/10.1007/s11011-013-9433-z | |
dc.description.abstract | Schizophrenia is causally associated with early-life
environmental stress, implicating oxidative stress in its pathophysiology.
N-acetyl cysteine (NAC), a glutathione precursor
and antioxidant, is emerging as a useful agent in the adjunctive
treatment of schizophrenia and other psychiatric illnesses.
However, its actions on brain monoamine metabolism are
unknown. Social isolation rearing (SIR) in rats presents with
face, predictive and construct validity for schizophrenia. This
study evaluated the dose-dependent effects of NAC (50, 150
and 250 mg/kg/day × 14 days) on SIR- vs. socially reared
induced changes in cortico-striatal levels of dopamine (DA),
serotonin (5-HT) noradrenaline (NA) and their associated metabolites.
SIR induced significant deficits in frontal corticalDA
and its metabolites, 3,4-dihydroxyphenylacetic acid (Dopac)
and homovanillic acid (HVA), reduced 5-HT and its metabolite,
5-hydroxyindoleacetic acid (5-HIAA), and reduced levels
of the NA metabolite, 3-methoxy-4-hydroxyphenylglycol
(MHPG). In addition, significant elevations in frontal cortical
NA and striatal DA, Dopac, HVA, 5-HT, 5-HIAA, NA and
MHPG were also observed in SIR rats. NAC at 150 and
250 mg/kg reversed all cortico-striatal DA, Dopac, HVA, 5-
HT, 5-HIAA and striatal NA alterations in SIR animals, with
250 mg/kg of NAC also reversing alterations in cortico-striatal
MHPG. In conclusion, SIR profoundly alters cortico-striatal
DA, 5-HT and NA pathways that parallel observations in
schizophrenia, while these changes are dose-dependently reversed
or abrogated by sub-chronic NAC treatment. A modulatory
action on cortico-striatal monoamines may explain
NACs’ therapeutic use in schizophrenia and possibly other
psychiatric disorders, where redox dysfunction or oxidative
stress is a causal factor. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.subject | N-acetyl cysteine | en_US |
dc.subject | Monoamines | en_US |
dc.subject | Social isolation rearing | en_US |
dc.subject | Frontal cortex | en_US |
dc.subject | Striatum | en_US |
dc.subject | Schizophrenia | en_US |
dc.title | N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 21247250 - Möller Wolmarans, Marisa | |
dc.contributor.researchID | 10060510 - Du Preez, Jan Lourens | |
dc.contributor.researchID | 11775416 - Viljoen, Francois Petrus | |
dc.contributor.researchID | 11083417 - Harvey, Brian Herbert | |