Conference Papers: Recent submissions
Now showing items 1-20 of 608
-
On the financial interpretation of risk contributions: an analysis using Quantile Simulation
(Taylor & Francis, 2019)This paper tests whether the financial interpretation of risk contributions (Qian, 2006), as measured by marginal change in volatility, holds when accounting for fat tails in the asset return distributions. This important ... -
Comparative evaluation of molecular based detection methods for drug resistant tuberculosis
(Elsevier, 2019)Tuberculosis (TB) is a globally problematic infectious disease. According to the World Health Organization (WHO) multidrug resistant tuberculosis (MDR-TB) has recently increased by an annual rate of N20%. In 2015; the ... -
The cardiovascular safety of Pheroid® in the conscious rat
(Elsevier, 2019)The Pheroid® technology is a patented colloidal drug delivery system comprised of a dispersed oil phase of omega 3 and omega 6 fatty acids emulsified in N2O saturated water. Pheroid® has pharmaceutical applicability for ... -
Evaluation of the in vitro antimicrobial activity of a Pheroid®- entrapped plant extract against human pathogens
(Elsevier, 2019)This plant extract (PE) has proven activity against fungi affecting crops in South Africa. However, there is currently insufficient data on the activity of the PE against human pathogens. The general aim of this study ... -
Determination of the therapeutic efficacy of a novel Pheroid® formulation in a rodent tuberculosis model
(Elsevier, 2019)Resistance against the current TB treatment regimens is spreading. A combination of the current TB regime with a novel drug delivery system, might lead to reduced resistance, shorter treatment durations and increased ... -
Development of an LC-MS/MS method for the quantification of goserelin from Pheroid® formulation
(Elsevier, 2019)The oral route is for many reasons the most common route of drug administration, however, due to gastrointestinal (GI) tract enzymatic stability issues, peptide drugs are administered parenterally. Goserelin is an ... -
Safety pharmacology of herbal medicines in South Africa
(Elsevier, 2019)The use of herbal medicine for treating various ailments has a deep history in South African traditional medicine. South Africa has a rich floral biodiversity which has been exploited for centuries mainly for day-to-day ... -
Elimination of host and dead pathogenic organism DNA for improved diagnostic outcome
(Elsevier, 2019)Molecular-based diagnostic techniques used to detect bacterial infections in clinical samples are often unable to discriminate between living and dead bacteria and extracellular DNA. This presents a major problem, leading ... -
Development of a batch process to produce ethylated fatty acid esters
(Elsevier, 2019)Pharmaceutical excipients account for the majority of the volume of administered drugs [1]. The problem with the manufacture of pharmaceutical excipients is that they were considered to be inert support material with ... -
Co-administration of African potato and cisplatin for treatingbreast and prostate cancers using a Pheroid® delivery system
(Elsevier, 2019)The cancer burden is increasing worldwide and is expected tobecome the most important barrier to increasing life expectancy 21stcentury. Low- and middle-income countries are expected to showthe biggest increase in incidence. ... -
Establishment and characterization of allograft and xenograft cancer rodent models
(Elsevier, 2019)To evaluate the efficacy of newly synthesized therapies prior to clinical trials, valid and true cancer models should be used [1]. For modelling cancer in vivo, transplantation of rodent (allograft) and human cancer ... -
Establishment and characterization of a murine HSV-2 model for the evaluation of a novel microbicide
(Elsevier, 2019)Herpes simplex virus −2 (HSV-2) is a serious global epidemic with an estimated 400 million people infected and about 20 million cases reported annually. The prevalence in South Africa is at 31% in females aged 15–29 ... -
The effect of entrapment of a peptide in Pheroid® on pharmacokinetics and testosterone levels
(Elsevier, 2019)Goserelin is a peptide drug that suppresses levels of testosterone and oestradiol [1]. The current formulation is presented in a sustained-release depot with several approved indications such as treatment of endometriosis, ... -
The use of cytokines as indicators for drug safety
(Elsevier, 2019)In developing new compounds, questions about safety and efficacy are raised. Conventional preclinical studies of new compounds focus on bio-distribution, toxicology, safety pharmacology, pharmacokinetics, efficacy etc., ... -
An investigation into the bioavailability of a peroral cannabinoid-Pheroid® formulation
(Elsevier, 2019)Cannabidiol (CBD), a phytocannabinoid isolated from the Cannabis sativa plant, has been investigated for its medicinal properties including anti-psychotic, anti- emetic, anti-inflammatory, anxiolytic and anti- convulsant ... -
Evaluation of the oral delivery of a peptide with Pheroid® technology
(Elsevier, 2019)Goserelin is a type of hormone therapy used in addition to standard adjuvant therapy. Currently, goserelin is only available as a slow releasing subcutaneous implant but this is an invasive and generally not well- tolerated ... -
Therapeutic use and pharmacological safety of herbal medicines
(Elsevier, 2019)In general, N80% of the world's population relies on traditional medicine for their primary healthcare [1]. The use of complementary herbal medicine provides an alternative option to modern allopathic treatment for ... -
The selective targeting of cancer cells by using Pheroid® as a drug delivery system
(Elsevier, 2019)Pheroid® is a drug delivery system with possible use in the treatment of chronic diseases such as cancer and that enhances the efficacy of the treatment of chronic diseases [1]. Current cancer treatment is non-selective, ... -
In vitro determination of the preclinical safety of Pheroid® doxorubicin formulations using patch clamp assays
(Elsevier, 2019)One of the most active, widely used and well-known drugs in breast cancer chemotherapy, doxorubicin (DOX), is an anthracycline ring antibiotic derived from the bacteria Streptomyces peucetius. Its clinical use is however, ... -
Pharmacoepidemiology capacity building in the Latin American and African regions
(Wiley, 2019)Background: An electronic screening survey of pharmacoepidemiology (PE) capacity building was developed for the Latin America (LatAm) and African regions. The objective of the screening survey was to identify a target ...