Browsing Conference Papers by Author "26419904 - Hayeshi, Rose Khavogoi"
Now showing items 1-6 of 6
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Co-administration of African potato and cisplatin for treating breast and prostate cancers using a Pheroid® delivery system
Lambert, Maarten; Okem, Ambrose; Hayeshi, Rose; De Graaf, Inge (Elsevier, 2019)The cancer burden is increasing worldwide and is expected tobecome the most important barrier to increasing life expectancy 21stcentury. Low- and middle-income countries are expected to showthe biggest increase in incidence. ... -
Development of an LC-MS/MS method for the quantification of goserelin from Pheroid® formulation
Takyi-Williams, John; Erasmus, Linné; Hayeshi, Rose; Grobler, Anne; Magwaza, Martin (Elsevier, 2019)The oral route is for many reasons the most common route of drug administration, however, due to gastrointestinal (GI) tract enzymatic stability issues, peptide drugs are administered parenterally. Goserelin is an ... -
The effect of entrapment of a peptide in Pheroid® on pharmacokinetics and testosterone levels
Hayeshi, Rose; Erasmus, Linné; Scholtz, Liezl-Marie; Venter, Kobus; Bester, Cor; Fick, Antoinette; Leussa, Nyango-Nkeh Adrienne; Grobler, Anne (Elsevier, 2019)Goserelin is a peptide drug that suppresses levels of testosterone and oestradiol [1]. The current formulation is presented in a sustained-release depot with several approved indications such as treatment of endometriosis, ... -
Establishment and characterization of a murine HSV-2 model for the evaluation of a novel microbicide
Kgoe, T.O.; Okem, A.; Hayeshi, R.; Damelin, L. (Elsevier, 2019)Herpes simplex virus −2 (HSV-2) is a serious global epidemic with an estimated 400 million people infected and about 20 million cases reported annually. The prevalence in South Africa is at 31% in females aged 15–29 ... -
Establishment and characterization of allograft and xenograft cancer rodent models
Koatale, Palesa; Okem, Ambrose; Venter, Kobus; Fick, Antoinette; Bester, Cor; Hayeshi, Rose (Elsevier, 2019)To evaluate the efficacy of newly synthesized therapies prior to clinical trials, valid and true cancer models should be used [1]. For modelling cancer in vivo, transplantation of rodent (allograft) and human cancer ... -
Evaluation of the oral delivery of a peptide with Pheroid® technology
Erasmus, Linné; Scholtz, Liezl-Marie; Venter, Kobus; Bester, Cor; Fick, Antoinette; Mabena, Jacob; Grobler, Anne; Hayeshi, Rose (Elsevier, 2019)Goserelin is a type of hormone therapy used in addition to standard adjuvant therapy. Currently, goserelin is only available as a slow releasing subcutaneous implant but this is an invasive and generally not well- tolerated ...