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dc.contributor.authorDu Plessis, Lissinda H.
dc.contributor.authorVan Niekerk, Anel C.
dc.contributor.authorMaritz, Marlene M.
dc.contributor.authorKotzé, Awie F.
dc.date.accessioned2014-07-09T10:08:20Z
dc.date.available2014-07-09T10:08:20Z
dc.date.issued2012
dc.identifier.citationDu Plessis, L.H. et al. 2012. In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum. Journal of antibiotics, 65(12):609-614. [https://doi.org/10.1038/ja.2012.89]en_US
dc.identifier.issn0021-8820
dc.identifier.issn1881-1469
dc.identifier.urihttp://hdl.handle.net/10394/10852
dc.identifier.urihttps://www.nature.com/articles/ja201289
dc.identifier.urihttps://doi.org/10.1038/ja.2012.89
dc.description.abstractThe macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been demonstrated. In this study, we investigated the enhancement of the efficacy of these antibiotics in combination with a patented lipid-based drug delivery system, Pheroid technology. A chloroquine resistant strain of Plasmodium falciparum (RSA11) was incubated with the formulations for a prolonged incubation time (144 h). Drug efficacy assays were conducted by analyzing the histidine-rich protein II levels of the parasites. The effects of azithromycin and erythromycin were compared with other antibiotics and standard antimalarial drugs. The poor water soluble nature of the drugs led to the formation of micro scale Pheroid vesicles with average particle sizes of 72.76±10.73 μm for azithromycin and 100.62±29.27 μm for erythromycin. The IC50 values of erythromycin and azithromycin alone and entrapped in Pheroid vesicles decreased statistically significant (P  0.05). Prolonged exposure was also statistically meaningful (P  0.05), although it seems that exposure need not exceed 96 h. Pheroid vesicles also proved successful in decreasing the IC50 values of doxycycline, tetracycline and triclosan. Pheroid vesicles containing antibiotics could prove successful as a malaria treatment option.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectAzithromycinen_US
dc.subjectErythromycinen_US
dc.subjectHRP II ELISA assayen_US
dc.subjectLipid-based drug delivery systemen_US
dc.subjectMalariaen_US
dc.subjectPheroid vesiclesen_US
dc.subjectPlasmodium falciparumen_US
dc.titleIn vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparumen_US
dc.typeArticleen_US
dc.contributor.researchID11948388 - Du Plessis, Lissinda Hester
dc.contributor.researchID10200142 - Kotzé, Abraham Frederik
dc.contributor.researchID12692123 - Maritz, Marlene M.


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