Browsing by Subject "Xenobiotics"
Now showing items 1-7 of 7
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The establishment of a model system in which variants of the medium-chain ligase (ACSM) and glycine N-acyltransferase (GLYAT) can be co-expressed and analysed
(North-West University (South Africa), 2022)Even though glycine conjugation pathway discovery dates back to the 18th century, it is still an important detoxification pathway that is severely neglected in research. Xenobiotics are omnipresent in the environment (as ... -
Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation
(Taylor & Francis, 2013)Introduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A ... -
The identification of genetic variation in the acyl-CoA synthetase genes (ACSM2A and ACSM2B)
(North-West University (South Africa), Potchefstroom Campus, 2016)Investigations into the role of the glycine conjugation pathway and specifically the functioning and significant importance of the mitochondrial medium-chain ligases have seriously been neglected over the last 30 years. ... -
Investigation and characterisation of the genetic variation in the coding region of the glycine N-acyltransferase gene
(North-West University, 2015)Thorough investigation of the glycine conjugation pathway has been neglected over the last 30 years. Environmental factors, nutrition, and the chronic use of medications are increasing the exposure of humans to benzoate ... -
The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour
(Taylor & Francis, 2018)Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA). Objective: We ... -
Phase I and II biotransformation in patients with chronic fatigue
(North-West University (South Africa), 2020)This thesis, titled: ‘Phase I and II biotransformation in patients with chronic fatigue’, forms part of the research and development programme of the Centre for Human Metabolomics at the NWU. There is no consensus definition ... -
Uridine diphosphate-glucuronosyltransferase (UGT) 2B subfamily interspecies differences in carnivores
(Oxford Univ Press, 2017)UDP-glucuronosyltransferases (UGTs) are among the most important xenobiotic metabolizing enzymes that conjugate a wide range of chemicals. Previous studies showed that Felidae and Pinnipedia species have very low UGT ...
