Browsing by Subject "Social isolation rearing"
Now showing items 1-10 of 10
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Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)Purpose: Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ... -
Development and validation of an animal model of treatment-resistant depression with psychotic features
(North-West University (South-Africa), 2021)Major depression (MD) affects up to 17% of the global population. While effective treatments for MD exist, an underlying interaction between genetic propensity and chronic and/or early life adversity may render these drugs ... -
Effects of chronic methamphetamine exposure during early or late phase development in normal and social isolation reared rats
(North-West University, 2012)Methamphetamine (MA) abuse is a fast growing drug problem, and is the second most widely abused drug world-wide. MA abuse has been linked to the development of symptoms indistinguishable from schizophrenia, referred to as ... -
The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical n-methyl-d-aspartate and d1 receptor binding in rats
(Elsevier, 2010)Glutamate and dopamine disturbances are implicated in frontal cortical dysfunction in schizophrenia. Little, however, is known about the nature of dopamine D1 and N-methyl-d-aspartate (NMDA) receptor interactions in the ... -
Evaluation of agomelatine treatment on neuroendocrine and behavioural markers in social isolation reared rats
(North-West University (South Africa) , Potchefstroom Campus, 2016)Anxiety disorders are extremely prevalent and co-morbid in psychiatric disorders with a complex neurobiology and aetiology. Current treatment options are not sufficiently effective and there is therefore a demand for new ... -
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
(Springer, 2013)Schizophrenia is causally associated with early-life environmental stress, implicating oxidative stress in its pathophysiology. N-acetyl cysteine (NAC), a glutathione precursor and antioxidant, is emerging as a useful ... -
Neurodevelopmental animal models reveal the convergent role of neurotransmitter systems, inflammation, and oxidative stress as biomarkers of schizophrenia: implications for novel drug development
(ACS, 2015)Schizophrenia is a life altering disease with a complex etiology and pathophysiology, and although antipsychotics are valuable in treating the disorder, certain symptoms and/or sufferers remain resistant to treatment. ... -
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment
(Elsevier, 2012)Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium requires further study. Altered tryptophan metabolism has been described in schizophrenia, possibly linked to ... -
Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
(Elsevier, 2013)Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine release . N-acetyl cysteine ... -
Studies into the anxiolytic actions of agomelatine in social isolation reared rats: role of corticosterone and sex
(Sage, 2018)Anxiety disorders are severely disabling, while current pharmacological treatments are complicated by delayed onset, low remission rates and side-effects. Sex is also noted to contribute towards illness severity and treatment ...