Browsing by Subject "Ritonavir"
Now showing items 1-3 of 3
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The development of ritonavir and pyrimethamine amorphous solid dispersions
(North-West University (South-Africa), 2021)Poorly soluble drugs are a major problem in the pharmaceutical industry. Not only does it lead to formulation difficulties, but it also leads to poor absorption and poor bioavailability of drugs. Ritonavir (RTV) is a ... -
Evidence for time-dependent interactions between ritonavir and lopinavir/ritonavir plasma levels following P-glycoprotein inhibition in Sprague-Dawley rats
(Pharmaceutical Society of Japan, 2011)The interaction between verapamil, a P-glycoprotein (P-gp) inhibitor, with ritonavir and lopinavir/ritonavir (LPV/r) after acute and chronic treatment was investigated in rats. Rats were divided into 4 groups, viz. Group ... -
Triglyceride values after six months of lopinavir/ritonavir therapy as an indicator for pancreatitis risk
(North-West University (South Africa) , Potchefstroom Campus, 2016)Pancreatitis is the inflammation of the pancreas with varying aetiology. Hypertriglyceridaemia (HTG) is known to cause pancreatitis at triglyceride (TG) values of 11.3 mmol/L and beyond. The protease inhibitors (PIs) – ...