Browsing by Subject "Rhodamine 123"
Now showing items 1-10 of 12
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Capsaicin and piperine as functional excipients for improved drug delivery across nasal epithelial models
(Thieme, 2019)The fruit from various pepper plants has been employed for the seasoning of food, as perfuming agents, and also as traditional medicines. Phytochemicals isolated from different pepper species have been found to modulate ... -
Comparison of rat and porcine jejunum as in vitro models for P–glycoprotein mediated efflux using the Sweetana–Grass diffusion method
(North-West University, 2010)Absorption of drug substances across the intestinal epithelium is a complex and dynamic process. Counter transport proteins are responsible for the efflux of specific drug molecules after they have been absorbed. One of ... -
The effect of different modulators on the transport of rhodamine 123 across rat jejunum using the sweetana-grass diffusion method
(North-West University, 2004)P-glycoprotein (Pgp), which leads to multidrug resistance in tumour cells, is an ATP-dependent secretory drug efflux pump. In the intestine, as well as at specific other epithelial and endothelial sites, P-glycoprotein ... -
The effect of selected hydroxy flavonoids on the in vitro efflux transport of rhodamine 123 using rat jejunum
(North-West University, 2005)Background: Multidrug resistance (MDR) is resistance of cancer cells to multiple classes of chemotherapeutic drugs that can be structurally unrelated. MDR involves altered membrane transport that results in a lower cell ... -
The effect of selected methoxy flavonoids on the in vitro efflux transport of rhodamine 123 using rat jejunum
(North-West University, 2005)Many orally administered drugs must overcome several barriers before reaching their target site. The first major obstacle to cross is the intestinal epithelium. Although lipophilic compounds may readily diffuse across the ... -
The effects of selected health supplements on drug intestinal epithelial permeation
(North-West University (South-Africa), 2019)With the growing popularity of health supplement usage to support and maintain a healthy body there is an increasing concern for possible drug-drug and drug-supplement interactions because health supplements are not subjected ... -
Effects of selected pharmaceutical excipients on drug permeation at different gastro-intestinal tract regions
(North-West University (South Africa) , Potchefstroom Campus, 2016)Although pharmaceutical excipients are considered pharmacologically inert, some excipients in dosage forms have shown an effect on the pharmacokinetics of certain drugs. This could be due to different mechanisms such as ... -
Evaluation of the effects of selected disintegrants on drug membrane permeation
(North-West University (South Africa) , Potchefstroom Campus, 2016)Virtually all solid dosage forms contain a disintegrating agent to help facilitate breakup, dissolution and absorption. Traditionally, excipients were thought to be pharmacologically inert, but recently, an increasing ... -
An ex vivo investigation of the potential drug permeation enhancing effects of selected pepper extracts
(North-West University (South-Africa), 2019)Although the oral route is the most preferred and convenient route of drug administration when considering the patient, certain drugs (e.g. protein and peptide drugs) are mostly administrated by means of injections. This ... -
Excipient-drug pharmacokinetic interactions: effect of disintegrants on efflux across excised pig intestinal tissues
(Elsevier, 2018)Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics. Pharmacokinetic interactions ...