Browsing by Subject "Pharmacokinetics"
Now showing items 1-10 of 15
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All-atomistic molecular dynamics (AA-MD) studies and pharmacokinetic performance of PAMAM-dendrimer-furosemide delivery systems
(Elsevier, 2018)Improvement of problematic dissolution and solubility properties of a model drug, furosemide, was investigated for poly(amidoamine) (PAMAM) dendrimer complexes of the drug. Full and half generation dendrimers with amino ... -
Antimalarial and anticancer activities of artemisinin-quinoline hybrid-dimers and pharmacokinetic properties in mice
(Elsevier, 2012)Malaria, one of the three most important life-threatening infectious diseases, is recommended to be treated with ACT (artemisinin combination therapy) against which Plasmodium falciparum already displayed resistance. Two ... -
Artemisinin–quinoline hybrids : design, synthesis and antimalarial activity
(North-West University, 2013)Introduction - Malaria is a major global health problem, with more than 500 million reported cases and at least 1 million deaths each year. The main problem with malaria control is the emerging drug resistance. Plasmodium ... -
A clinical investigation into the bioavailability of a peroral cannabinoid-Pheroid® formulation
(North-West University (South-Africa), 2020)The therapeutic advantages of pure Cannabidiol (CBD), a phytocannabinoid isolated from the Cannabis sativa L. plant, are emphasised by the growing use of CBD in numerous conditions ranging from supplementary to the treatment ... -
Combination therapy of western drugs and herbal medicines: recent advances in understanding interactions involving metabolism and efflux
(Taylor & Francis, 2012)Introduction: While complementary and alternative medicine markets prosper with an increasing number of consumers of herbal medicines, there is an associated likelihood for herb–drug interactions to occur. Modulation of ... -
The development and evaluation of a novel hybrid PLGA nanoparticle-Pheroid® with the potential to improve tuberculosis therapy
(North-West University, Potchefstroom Campus, 2018)The development of drug delivery technologies has the potential to bring both therapeutic and commercial value to future healthcare products. Drug delivery technologies are transport vehicles that help overcome the ... -
The effect of the Pheroid delivery system on the in vitro metabolism and in vivo pharmacokinetics of artemisone
(Taylor & Francis, 2014)Objectives: The objectives were to determine the pharmacokinetics (PK) of artemisone and artemisone formulated in the Pheroid® drug delivery system in primates and to establish whether the formulation affects the in vitro ... -
Enhancement of nasal drug delivery by means of beneficial pharmacokinetic interactions
(North-West University (South-Africa), 2020)Drug products and dosage forms are seldom taken in complete isolation. The possibility exist to ingest drugs together with foods, herbs, dietary supplements and/or other drugs, which may result in pharmacokinetic or ... -
Evaluation of the oral delivery of goserelin with Pheroid® technology
(North-West University (South-Africa), 2019)The therapeutic amphiphilic peptide, goserelin, being investigated in these studies, is a type of hormone therapy generally used in addition to standard adjuvant therapy. Goserelin serves as treatment for numerous ... -
Impact of traditional African medicine on drug metabolism and transport
(Taylor & Francis, 2014)Introduction: Africa is a continent of rich plant biodiversity with many indigenous plants having a long history of being used for medicinal purposes. A considerable number of patients consult traditional healers in ...