Browsing by Subject "Parkinson’s disease (PD)"

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    • Affinity of dihydropyrimidone analogues for adenosine A1 and A2A receptors 

      Katsidzira, Runako Masline (2014)
      Parkinson’s disease (PD) is a neurodegenerative disorder that is characterised by a reduction of dopamine concentration in the striatum due to degeneration of dopaminergic neurons in the substantia nigra. Currently, first ...

    • Inhibition of monoamine oxidase by indole and benzofuran derivatives 

      Prins, Louis H.A.; Petzer, Jacobus P.; Malan, Sarel F. (Elsevier, 2010)
      Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. A series of indole and benzofuran derivatives were synthesised and evaluated as inhibitors of the two MAO isoforms, MAO-A and ...