Browsing by Subject "GCxGC-TOFMS"
Now showing items 1-10 of 12
-
Assessment of polar organic aerosols at a regional background site in southern Africa
(Springer, 2019)A recent paper reported GCxGC-TOFMS analysis used for the first time in southern Africa to tentatively characterise and semi-quantify ~1000 organic compounds in aerosols at Welgegund – a regional background atmospheric ... -
Characterising particulate organic nitrogen at a savannah-grassland region in South Africa
(MDPI, 2019)Although atmospheric organic N compounds are considered to be important, especially in new particle formation and their contribution to brown carbon, these species are not that well understood. This can be partially ... -
Characterising tuberculosis treatment success and failure using metabolomics
(North-West University, 2013)Tuberculosis (TB) is one of the deadliest infectious diseases of our time, with 1.4 million deaths globally, recorded in 2010 (3800 deaths a day) by the World Health Organization (WHO). Currently, South Africa ranks third ... -
A comparison of four sputum pre-extraction preparation methods for identifying and characterising Mycobacterium tuberculosis using GCxGC-TOFMS metabolomics
(Elsevier, 2012)In many pulmonary diseases, sputum is a valuable sample material for use in disease characterisation and diagnostics. However, due to its high viscosity and uneven consistency (lumpiness), it is difficult to obtain ... -
The effect of sex and HIV on the TB-induced altered sputum metabolome
(North-West University (South Africa), 2023)Various studies have identified TB-induced metabolome variations. However, in most of these studies, the unaccounted-for variation between individual patients is noteworthy. To investigate one potential cause of this ... -
Measurement of organic compounds in atmospheric aerosols collected at Welgegund, South Africa
(North-West University, 2018)Atmospheric aerosols or particulate matter (PM) are a complex mixture of solid and liquid particulates suspended in the atmosphere that originate from natural and anthropogenic sources. These species influence climate ... -
A metabolomics investigation of the function of the ESX-1 gene cluster in mycobacteria
(Elsevier, 2016)The ESX-1 gene cluster, encoding the Type-VII secretion (T7S) system and its virulence associated proteins, ESAT-6 and CFP-10, is thought to be responsible for the transport of extracellular proteins across the hydrophobic ... -
Mycobacterium tuberculosis curli pili (MTP) is associated with significant host metabolic pathways in an A549 epithelial cell infection model and contributes to the pathogenicity of Mycobacterium tuberculosis
(Springer, 2020)Introduction A clear understanding of the metabolome of Mycobacterium tuberculosis and its target host cell during infection is fundamental for the development of novel diagnostic tools, effective drugs and vaccines ... -
Mycobacterium tuberculosis curli pili (MTP) is associated with significant host metabolic pathways in an A549 epithelial cell infection model and contributes to the pathogenicity of Mycobacterium tuberculosis
(Springer, 2020)Introduction A clear understanding of the metabolome of Mycobacterium tuberculosis and its target host cell during infection is fundamental for the development of novel diagnostic tools, effective drugs and vaccines ... -
Size-resolved characterisation of organic compounds in atmospheric aerosols collected at Welgegund, South Africa
(Springer, 2015)The organic fraction of atmospheric aerosols is 20 to 90 % of which only a small percentage has been chemically characterised. Two-dimensional gas chromatography with a time-of-flight mass spectrometer (GCxGC-TOFMS) is a ...
