Browsing by Subject "Drug design"

Now showing items 1-3 of 3

Caffeine as a lead compound for the design of therapeutic agents for the treatment of Parkinson’s disease

Petzer, Jacobus P.; Petzer, Anél (Bentham Science, 2015)

The current pharmacological therapies for the treatment of Parkinson’s disease are mostly inadequate and recent, improved therapeutic agents are required. Two important molecular targets for the design of anti-parkinsonian ...
Multifunctional enzyme inhibition for neuroprotection: a focus on MAO, NOS, and AChE inhibitors

Joubert, Jacques; Petzer, Jacobus P.; Repsold, Benjamin P.; Prins, Louis H.A.; Malan, Sarel F. (Elsevier, 2015)

Neurodegenerative disorders are known to be multifactorial in nature and current research focus has moved from a ‘one-drug-one-target approach’ to that of drugs which are able to act at various relevant biological targets. ...
A review of the pharmacological properties of 3,4-dihydro-2(1h)- quinolinones

Meiring, Letitia; Petzer, Jacobus P.; Petzer, Anél (Bentham Science, 2018)

The 3,4-dihydro-2(1H)-quinolinone moiety is present in a number of pharmacologically active compounds. These include FDA approved drugs such as cilostazol, carteolol and aripiprazole as well as numerous experimental ...