Browsing by Subject "DprE1"

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Quinolone analogues of benzothiazinone: Synthesis, antitubercular structure-activity relationship and ADME profiling

Dube, Phelelisiwe S.; Legoabe, Lesetja J.; Joordan, Audrey; Sigauke, Lester; Warner, Digby F.; Beteck, Richard M. (Elsevier, 2023)

Mycobacterium tuberculosis (Mtb) has an impermeable cell wall which gives it an inherent ability to resist many antibiotics. DprE1, an essential enzyme in Mtb cell wall synthesis, has been validated as a target for several ...
Synthesis and in vitro anti-tubercular evaluation of 6-nitroquinolone-3-carboxamides

Dube, P.S. (North-West University (South Africa), 2020)

Tuberculosis (TB) is a disease that has been a major scourge of humankind since time immemorial. It is an airborne disease that mainly affects the lungs and it is caused by Mycobacterium tuberculosis (Mtb)─ a pathogenic ...