Browsing by Subject "Circulating DNA"
Now showing items 1-6 of 6
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Characterization of circulating free DNA in healthy and diseased individuals
(North-West University, 2009)Circulating DNA is small fragments of DNA present in the blood of vertebrates. Even though the origin, function and significance of these DNA fragments are not elucidated yet, it is widely investigated as a source of ... -
Continuous adaptation through genetic communication: a putative role for cell-free DNA
(Taylor & Francis, 2012)Introduction: The virtosome fraction of cell-free DNA, being newly synthesised, capable of horizontal gene transfer (HGT) and subsequent genomic incorporation and expression, may play crucial roles in the biological functions ... -
Is the role of circulating DNA as a biomarker of cancer being prematurely overrated?
(Elsevier, 2010)Background Circulating DNA is utilized widely as a genetic biomarker in a variety of pathological conditions, mainly in cancerous conditions. Quantification of circulating DNA and identifying the frequencies of a variety ... -
Kinetic analysis, size profiling, and bioenergetic association of DNA released by selected cell lines in vitro
(Springer, 2017)Although circulating DNA (cirDNA) analysis shows great promise as a screening tool for a wide range of pathologies, numerous stumbling blocks hinder the rapid translation of research to clinical practice. This is related ... -
Origin, translocation and destination of extracellular occurring DNA: a new paradigm in genetic behaviour
(Elsevier, 2011)The diagnostic value of extracellular occurring DNA (eoDNA) is limited by our lack of understanding its biological function. eoDNA exists in a number of forms, namely vesicle bound DNA (apoptotic bodies, micro particles, ... -
Transmission of clinical risk factors through circulating DNA
(North-West University (South Africa), Potchefstroom Campus, 2017)Newly synthesised, actively released circulating DNA can translocate to neighbouring and remote parts of the body, enter cells and alter their biology. It has been implicated in the bystander effect, tumour development ...
