Browsing by Subject "Chloroquine (CQ)"

Now showing items 1-3 of 3

Preparation, stability and in vitro evaluation of liposomes containing chloroquine

Nieuwoudt, Stephnie (North-West University, 2010)

Malaria is currently a huge treat worldwide, as far as infections are concerned, and is responsible for thousands of deaths per annum. The dilemma associated with the development of anti–malarial drug resistance over the ...
Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids

Pretorius, Stefan I.; Breytenbach, Wilma J.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2013)

The aim of this study was to synthesize a series of quinoline–pyrimidine hybrids and to evaluate their in vitro antimalarial activity as well as cytotoxicity. The hybrids were brought about in a two-step nucleophilic s ...
Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides

Smit, Frans J.; N'Da, David D. (Elsevier, 2014)

A series of 4-aminoquinolinyl-chalcone amides 11–19 were synthesized through condensation of carboxylic acid-functionalized chalcone with aminoquinolines, using 1,10-carbonyldiimidazole as coupling agent. These compounds ...