Browsing by Subject "Acridine"

Now showing items 1-2 of 2

Synthesis and antimalarial activity screening of artemisinin-acridine hybrids

Joubert, Juan Paul (2013)

Malaria endemic areas not only pose a public health threat, but affects 3.3 billion people worldwide. In 2011, estimated malaria related deaths amounted to 660 000 out of 219 million reported cases, with 81% of these and ...
Synthesis and in vitro biological evaluation of aminoacridines and artemisinin-acridine hybrids

Joubert, Juan P.; Smit, Frans J.; Du Plessis, Lissinda; N'Da, David D.; Smith, Peter J. (Elsevier, 2014)

During this study, 9-aminoacridine and artemisinin–acridine hybrid compounds were synthesized and the in vitro for antimalarial activity against both the chloroquine sensitive but also gametocytocidal strain (NF54), and ...