Browsing by Author "10055037 - Reinecke, Carolus Johannes"
Now showing items 21-29 of 29
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Metabolomics variable selection and classification in the presence of observations below the detection limit using an extension of ERp
Van Reenen, Mari; Westerhuis, Johan A.; Reinecke, Carolus J.; Venter, J. Hendrik (BioMed Central, 2017)Background ERp is a variable selection and classification method for metabolomics data. ERp uses minimized classification error rates, based on data from a control and experimental group, to test the null hypothesis of ... -
Organic acid profile of isovaleric acidemia: a comprehensive metabolomics approach
Dercksen, Marli; Koekemoer, Gerhard; Mienie, Lodewyk J.; Reinecke, Carolus J.; Duran, Marinus (Springer, 2013)Isovaleric acidemia (IVA, MIM 248600) can be a severe and potentially life-threatening disease in affected neonates, but with a positive prognosis on treatment for some phenotypes. This study presents the first ... -
Polyunsaturated fatty acid status in treated isovaleric acidemia patients
Dercksen, M.; Mienie, L.J.; Reinecke, C.J.; Kulik, W.; Wanders, R.J.A. (Springer Nature, 2016)BACKGROUND/OBJECTIVES: Nutritional deficiencies are frequently observed when treating patients with inborn errors of metabolism due to an unbalanced diet. Thus far, patients with isovaleric acidemia (IVA) who adhere to a ... -
A putative urinary biosignature for diagnosis and follow-up of tuberculous meningitis in children: outcome of a metabolomics study disclosing host-pathogen responses
Mason, Shayne; Van Reenen, Mari; Reinecke, Carolus J.; Solomons, Regan; Wevers, Ron A. (Springer, 2016)Introduction: Tuberculous meningitis (TBM) is a severe manifestation of tuberculosis, presenting with high morbidity and mortality in children. Existing diagnostic methods for TBM are invasive and time-consuming and the ... -
Qualitative serum organic acid profiles of HIV-infected individuals not on antiretroviral treatment
Williams, Aurelia; Koekemoer, Gerhard; Lindeque, Zander; Reinecke, Carolus; Meyer, Debra (Springer, 2012)The first application of gas chromatography mass spectrometry (GC–MS) metabolomics to the analysis of organic acid profiles in sera of asymptomatic human immunodeficiency virus (HIV)-infected individuals (n = 18) ... -
Single nucleotide and copy number polymorphisms of the SULT1A1 gene in a South African Tswana population group
Mbongwa, Hlengiwe P.; Pretorius, Petrus J.; Kruger, Annemarie; Koekemoer, Gerhard; Reinecke, Carolus J. (ASSAf, 2011)Previous studies on gene mapping have firmly established variation in segments of the DNA structure amongst different population groups. SULT1A1 is one of four SULT1A genes that maps to the short arm of chromosome 16, ... -
The Th1/Th2/Th17 cytokine profile of HIV-infected individuals: a multivariate cytokinomics approach
Williams, Aurelia; Reinecke, Carolus; Steffens, Francois; Meyer, Debra (Elsevier, 2013)HIV infection causes the dysregulation of cytokine production. A cytokinomics approach employing cytometric bead array (CBA) technology, flow cytometry and multivariate analysis was applied to the investigation of ... -
Tuberculous meningitis in infants and children: insights from nuclear magnetic resonance metabolomics
Mason, Shayne; Reinecke, Carolus J.; Solomons, Regan; Van Furth, A. Marceline (ASSAf, 2016)Tuberculous meningitis (TBM) is a prevalent form of central nervous system tuberculosis (CNS-TB) and the most severe common form of bacterial meningitis in infants and children below the age of 13 years, especially in ... -
Variable selection for binary classification using error rate p-values applied to metabolomics data
Van Reenen, Mari; Reinecke, Carolus J.; Westerhuis, Johan A.; Venter, J. Hendrik (BioMed Central, 2016)Background: Metabolomics datasets are often high-dimensional though only a limited number of variables are expected to be informative given a specific research question. The important task of selecting informative variables ...