Browsing by Subject "Fluoxetine"
Now showing items 1-10 of 14
-
Antidepressant exposure reduces body size, increases fecundity and alters social behavior in the short-lived killifish Nothobranchius furzeri
(Elsevier, 2020)Social and mating behavior are fundamental fitness determinants in fish. Although fish are increasingly exposed to pharmaceutical compounds that may alter expression of such behavior, potential effects are understudied. ... -
Chronic effects of pre-adolescent pharmacological and non-pharmacological interventions on depressive-like behaviour in rats
(North-West University, 2018)Similar to adults, major depressive disorder (MDD) also affects children and adolescents, with comparable treatment outcomes. However, only two antidepressants, namely the serotonin reuptake inhibitors fluoxetine and ... -
Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment
(Elsevier, 2009)Motor stereotypies, described as repetitive, topographically invariant and seemingly purposeless behaviours, are common to several developmental and neuropsychiatric disorders. While drug induced stereotypy has been ... -
Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression
(Springer, 2016)Rationale The mechanisms mediating ketamine’s antidepressant effect have only been partly resolved. Recent preclinical reports implicate serotonin (5-hydroxytryptamine; 5-HT) in the antidepressant-like action of ketamine. ... -
Early-life exposure to fluoxetine and/or exercise on bio-behavioural markers of depression in early adulthood in stress sensitive rats
(North-West University (South Africa) , Potchefstroom Campus, 2015)Juvenile depression is a major concern worldwide, with only the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and escitalopram approved for treatment. The effects of early-life exposure to SSRIs on neurodevelopment ... -
Improving the reliability and ecological validity of pharmaceutical risk assessment: Turquoise killifish (Nothobranchius furzeri) as a model in behavioral ecotoxicology
(Wiley, 2019)Pharmaceuticals are essential for human well-being, but their increasing and continuous use pollutes the environment. Although behavioral ecotoxicology is increasingly advocated to assess the effects of pharmaceutical ... -
The involvement of nitric oxide in a rodent model of post-traumatic stress disorder
(North-West University, 2003)Post-traumatic stress disorder (PTSD), an anxiety disorder, may develop after experiencing or witnessing a severe traumatic event. Characteristic symptoms include hyper arousal and amnesic symptoms, while volume reductions ... -
Long-lasting effects of fluoxetine and/or exercise augmentation on bio-behavioural markers of depression in pre-pubertal stress sensitive rats
(Elsevier, 2017)Juvenile depression is of great concern with only limited treatment currently approved. Delayed onset of action, low remission and high relapse rates, and potential long-lasting consequences further complicates treatment ... -
The long-term effects of fluoxetine on stress-related behaviour and acute monoaminergic stress response in stress sensitive rats
(2014)Fluoxetine and escitalopram are the only antidepressants approved by the Food and Drug Administration of the United States of America (FDA) for treatment of major depression in children and adolescents. Both drugs are ... -
Long-term effects of pre-pubertal fluoxetine on behaviour and monoaminergic stress response in stress-sensitive rats
(Cambridge Univ Press, 2017)Although prescription rates of antidepressants for children and adolescents have increased, concerns have been raised regarding effects on neurodevelopment and long-term outcome. Using a genetic animal model of depression, ...