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dc.contributor.authorDe Brouwer, Geoffrey
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorWolmarans, De Wet
dc.date.accessioned2020-06-22T06:21:54Z
dc.date.available2020-06-22T06:21:54Z
dc.date.issued2020
dc.identifier.citationDe Brouwer, G. et al. 2020. Naturalistic operant responses in deer mice (Peromyscus maniculatus bairdii) and its response to outcome manipulation and serotonergic intervention. Behavioural pharmacology, 31(4):343-358. [https://doi.org/10.1097/FBP.0000000000000536]en_US
dc.identifier.issn0955-8810
dc.identifier.issn1473-5849 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/34839
dc.identifier.urihttps://journals.lww.com/behaviouralpharm/Abstract/2020/06000/Naturalistic_operant_responses_in_deer_mice.4.aspx
dc.identifier.urihttps://doi.org/10.1097/FBP.0000000000000536
dc.description.abstractInvestigating the motivational triggers underlying naturalistic compulsive-like behavior is generally regarded as challenging. To this extent, the current study aimed to establish a proof-of-concept for future investigation by probing unconditioned and naturalistic operant responses aimed at obtaining nesting material by normal (NNB) and large (LNB) nest building deer mice (Peromyscus maniculatus bairdii). LNB mice and NNB controls were individually placed in cages equipped with a lever-operated nesting material (cotton rope) dispenser and allowed to become accustomed to the response (lever press)-outcome (obtaining cotton rope) contingency over seven nights. Subsequently, the contingency was manipulated by withdrawing the nesting material (experiment 1) or punishing the lever-press response with a mild electrical foot shock (experiment 2). Mice were then treated for 28 days with escitalopram (50 mg/kg/d) and retested. Our results indicate that (1) LNB mice generally made more operant responses compared to NNB controls, (2) withdrawal of nesting material and institution of punishment bolstered responding in LNB but not NNB mice and (3) escitalopram treatment tended to reduce increased responding in LNB mice following experimental manipulation, while normalizing the total number of lever-press counts in the LNB cohort. Therefore, LNB seems to diverge from NNB, not only as a spontaneous phenotype, but also in terms of the motivation to obtain nesting material, despite demotivating feedback. That such differences were abrogated by chronic escitalopram intervention, indicates that the uniquely motivated operant interactions displayed by LNB mice, may be founded upon serotonergic mechanisms, a finding in line with the neurobiological theory of obsessive-compulsive disorderen_US
dc.language.isoenen_US
dc.publisherWolters Kluweren_US
dc.subjectCognitionen_US
dc.subjectDeer mouse modelen_US
dc.subjectEscitalopramen_US
dc.subjectLarge nest buildingen_US
dc.subjectLever-pressen_US
dc.subjectNaturalistic behavioren_US
dc.subjectObsessive-compulsive disorderen_US
dc.titleNaturalistic operant responses in deer mice (Peromyscus maniculatus bairdii) and its response to outcome manipulation and serotonergic interventionen_US
dc.typeArticleen_US
dc.contributor.researchID11083417 - Harvey, Brian Herbert
dc.contributor.researchID12324515 - Wolmarans, Petrus De Wet
dc.contributor.researchID23511990 - De Brouwer, Geoffrey


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